Prognostic nomogram for hepatocellular carcinoma patients after transarterial chemoembolization based on des-γ-carboxy prothrombin reactivity and modified Response Evaluation Criteria in Solid Tumors

• Published in: Journal of cancer research and therapeutics Vol. 17; no. 3; pp. 707 - 714
• Main Authors: Zhao, Su-Ming, Qiu, Li-Wei, Zhao, Hui, Gu, Wei-Wei, Yang, Xiao-Hu, Gu, Zhu-Xing, Shi, Rong-Feng, Ni, Cai-Fang
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer India Pvt. Ltd 01.07.2021; Medknow Publications & Media Pvt. Ltd
• Subjects: Adult; Aged; Aged, 80 and over; Biomarkers - blood; Carcinoma, Hepatocellular - blood; Carcinoma, Hepatocellular - diagnosis; Carcinoma, Hepatocellular - mortality; Carcinoma, Hepatocellular - therapy; Chemoembolization; Chemoembolization, Therapeutic; Clinical decision making; Clinical Decision-Making - methods; Female; Humans; Liver cancer; Liver Neoplasms - blood; Liver Neoplasms - diagnosis; Liver Neoplasms - mortality; Liver Neoplasms - therapy; Male; Medical prognosis; Middle Aged; Nomograms; Protein Precursors - blood; Prothrombin; Response Evaluation Criteria in Solid Tumors; Retrospective Studies; overall survival; transarterial chemoembolization; modified Response Evaluation Criteria in Solid Tumors; Des-γ-carboxy prothrombin; hepatocellular carcinoma
• ISSN: 0973-1482; 1998-4138
• DOI: 10.4103/jcrt.JCRT_651_20

Aims: The aim of this study was to construct a nomogram that will predict the overall survival (OS) of hepatocellular carcinoma (HCC) patients after transarterial chemoembolization (TACE). Materials and Methods: Imaging data, clinical characteristics, and serum des-γ-carboxy prothrombin (DCP) levels of 93 HCC patients treated with TACE were collected. Lasso regression, random forest, and other methods were used to screen the OS-related variables and construct the Cox prognosis model. The model was visualized by nomogram, and the net benefit of the clinical decision was assessed by decision curve analysis (DCA). Results: It was found that DCP level after TACE was an important predictor of OS in HCC patients. The OS of the patients with lower serum DCP levels after TACE was significantly better than the group with higher levels (P = 0.003). The Cox prognostic model was constructed using four predictors including DCP reactivity (P = 0.001), modified Response Evaluation Criteria in Solid Tumors (mRECIST, P = 0.005), Child-Pugh class (P = 0.018), and portal vein thrombosis (P = 0.039). The C-index of the nomogram for OS of patients after TACE was 0.813. The clinical decision-making net benefits based on the nomogram were better than the decision-making based on the TNM stage system. Conclusion: DCP reactivity and mRECIST are the key predictors of prognosis in HCC patients that received TACE as their initial treatment. The nomogram constructed with these two indicators as the core could predict the OS of HCC patients after TACE and help in clinical decision-making.