Hydrazone molecules as mimics for acetylcholinesterase. A new route towards disposable biosensors for pesticides?

• Published in: Sensors and actuators. B, Chemical Vol. 182; pp. 211 - 216
• Main Authors: Sgobbi, Livia F., Pinho, Vagner D., Cabral, Murilo F., Burtoloso, Antonio C.B., Machado, Sergio A.S.
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.06.2013
• Subjects: absorption; acetates; acetylcholine; Acetylcholinesterase; Acetylthiocholine hydrolysis; adsorption; benzoic acid; Biosensor; biosensors; blood; carbamate pesticides; enzyme activity; Fourier transform infrared spectroscopy; glucose; humans; hydrazine; hydrolysis; Mimetic molecule; Mimetic molecule; Acetylthiocholine hydrolysis; Acetylcholinesterase; Biosensor

Acetylcholinesterase has been widely used in the development of biosensors for pesticide detection. However, there are few reports approaching the application in real samples, mainly due to the low stability, high cost and lack of enzymatic activity by pesticides adsorption. An alternative is the re...