A newly identified flavoprotein disulfide reductase Har protects Streptococcus pneumoniae against hypothiocyanous acid

• Published in: The Journal of biological chemistry Vol. 298; no. 9; p. 102359
• Main Authors: Shearer, Heather L., Pace, Paul E., Paton, James C., Hampton, Mark B., Dickerhof, Nina
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.09.2022; American Society for Biochemistry and Molecular Biology
• Subjects: flavoprotein disulfide reductase; hypothiocyanous acid; lactoperoxidase; myeloperoxidase; pneumonia; pyridine nucleotide-disulfide reductase; SPD_1415; thioredoxin reductase; BHI; THY; hypothiocyanous acid; SOE; TNB; myeloperoxidase; LPO; GR; flavoprotein disulfide reductase; H2O2; HOSCN; MPO; thioredoxin reductase; SPD_1415; MWCO; pneumonia; IAM; FDR; CAT; Har; pyridine nucleotide-disulfide reductase; lactoperoxidase; SCN; TrxR

Hypothiocyanous acid (HOSCN) is an antimicrobial oxidant produced by heme peroxidases from hydrogen peroxide and thiocyanate anions in secretory fluids such as in the human respiratory tract. While some respiratory tract pathogens display tolerance to HOSCN, there might be therapeutic value in targe...