Reductive aminations by imine reductases: from milligrams to tons

• Published in: Chemical science (Cambridge) Vol. 13; no. 17; pp. 4697 - 4713
• Main Authors: Gilio, Amelia K, Thorpe, Thomas W, Turner, Nicholas, Grogan, Gideon
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 04.05.2022; The Royal Society of Chemistry
• Subjects: Amines; Asymmetry; Carbonyl compounds; Carbonyls; Catalysis; Chemical synthesis; Chemistry; Enzymes; Industrial applications; Production methods; Public domain; Reductases; Selectivity; Transition metals

The synthesis of secondary and tertiary amines through the reductive amination of carbonyl compounds is one of the most significant reactions in synthetic chemistry. Asymmetric reductive amination for the formation of chiral amines, which are required for the synthesis of pharmaceuticals and other b...