Central hemodynamics in a baboon model during microgravity induced by parabolic flight
We developed a chronically instrumented nonhuman primate model (baboon) to evaluate the central cardiovascular responses to transient microgravity induced by parabolic flight. Instrumentation provided simultaneous recording of high fidelity (Ao) and pulmonary artery (PA) pressures, right and left ve...
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Published in | Advances in space research Vol. 14; no. 8; pp. 349 - 358 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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Elsevier Ltd
01.01.1994
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Abstract | We developed a chronically instrumented nonhuman primate model (baboon) to evaluate the central cardiovascular responses to transient microgravity induced by parabolic flight. Instrumentation provided simultaneous recording of high fidelity (Ao) and pulmonary artery (PA) pressures, right and left ventricular and atrial pressures, Ao and PA blood flow velocities and vessel dimensions, ECG and pleural pressures. Four daily flights in 1991 and five in 1992 were flown with forty parabola per flight. Animals flown in 1991 were not controlled for volume status. Animals flown in 1992 were studied in one of three conditions: 1) volume depleted by furosemide (DH), 2) volume expanded by saline infusion (VE), and 3) euvolemic (EU, no intervention, used for echo only). Mean right atrial pressures (RAP) during 1991 flights had a variable early microgravity response: increases in n=3 and decrease in n=3 (supine) and increases in n=5, decreases in n=2 (upright). In 1992 flights, DH, upright and supine, changed −10 ± 4.1 mmHg, −3.2 ± 2.2 mmHg, respectively (p<.05) compared to the pull-up phase. In contrast, VE changed (from pull-up to microgravity) +13 ± 1.5 mmHg and +4.25 ± 2.9 mmHg (upright and supine, respectively, p <.05). EU increased with microgravity +6.9 ± .9 mmHg (upright only). LAP responses were similar, but more variable. Finally, heart chamber areas paralleled pressure changes. Thus, right and left heart filling pressure changes with sudden entry into microgravity conditions were dependent on initial circulatory volume status and somewhat modified by position (supine vs upright). |
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AbstractList | We developed a chronically instrumented nonhuman primate model (baboon) to evaluate the central cardiovascular responses to transient microgravity induced by parabolic flight. Instrumentation provided simultaneous recording of high fidelity (Ao) and pulmonary artery (PA) pressures, right and left ventricular and atrial pressures, Ao and PA blood flow velocities and vessel dimensions, ECG and pleural pressures. Four daily flights in 1991 and five in 1992 were flown with forty parabola per flight. Animals flown in 1991 were not controlled for volume status. Animals flown in 1992 were studied in one of three conditions: 1) volume depleted by furosemide (DH), 2) volume expanded by saline infusion (VE), and 3) euvolemic (EU, no intervention, used for echo only). Mean right atrial pressures (RAP) during 1991 flights had a variable early microgravity response: increases in n=3 and decrease in n=3 (supine) and increases in n=5, decreases in n=2 (upright). In 1992 flights, DH, upright and supine, changed −10 ± 4.1 mmHg, −3.2 ± 2.2 mmHg, respectively (p<.05) compared to the pull-up phase. In contrast, VE changed (from pull-up to microgravity) +13 ± 1.5 mmHg and +4.25 ± 2.9 mmHg (upright and supine, respectively, p <.05). EU increased with microgravity +6.9 ± .9 mmHg (upright only). LAP responses were similar, but more variable. Finally, heart chamber areas paralleled pressure changes. Thus, right and left heart filling pressure changes with sudden entry into microgravity conditions were dependent on initial circulatory volume status and somewhat modified by position (supine vs upright). We developed a chronically instrumented nonhuman primate model (baboon) to evaluate the central cardiovascular responses to transient microgravity induced by parabolic flight. Instrumentation provided simultaneous recording of high fidelity (Ao) and pulmonary artery (PA) pressures, right and left ventricular and atrial pressures, Ao and PA blood flow velocities and vessel dimensions, ECG and pleural pressures. Four daily flights in 1991 and five in 1992 were flown with forty parabola per flight. Animals flown in 1991 were not controlled for volume status. Animals flown in 1992 were studied in one of three conditions: 1) volume depleted by furosemide (DH), 2) volume expanded by saline infusion (VE), and 3) euvolemic (EU, no intervention, used for echo only). Mean right atrial pressures (RAP) during 1991 flights had a variable early microgravity response: increases in n=3 and decrease in n=3 (supine) and increases in n=5, decreases in n=2 (upright). In 1992 flights, DH, upright and supine, changed -10 +/- 4.1 mmHg, -3.2 +/- 2.2 mmHg, respectively (p < .05) compared to the pull-up phase. In contrast, VE changed (from pull-up to microgravity) +13 +/- 1.5 mmHg and +4.25 +/- 2.9 mmHg (upright and supine, respectively, p < .05). EU increased with microgravity +6.9 +/- .9 mmHg (upright only). LAP responses were similar, but more variable. Finally, heart chamber areas paralleled pressure changes. Thus, right and left heart filling pressure changes with sudden entry into microgravity conditions were dependent on initial circulatory volume status and somewhat modified by position (supine vs upright). We developed a chronically instrumented nonhuman primate model (baboon) to evaluate the central cardiovascular responses to transient microgravity induced by parabolic flight. Instrumentation provided simultaneous recording of high fidelity (Ao) and pulmonary artery (PA) pressures, right and left ventricular and atrial pressures, Ao and PA blood flow velocities and vessel dimensions, ECG and pleural pressures. Four daily flights in 1991 and five in 1992 were flown with forty parabola per flight. Animals flown in 1991 were not controlled for volume status. Animals flown in 1992 were studied in one of three conditions: 1) volume depleted by furosemide (DH), 2) volume expanded by saline infusion (VE), and 3) euvolemic (EU, no intervention, used for echo only). Mean right atrial pressures (RAP) during 1991 flights had a variable early microgravity response: increases in n=3 and decrease in n=3 (supine) and increases in n=5, decreases in n=2 (upright). In 1992 flights, DH, upright and supine, changed -10 +/- 4.1 mmHg, -3.2 +/- 2.2 mmHg, respectively (p < .05) compared to the pull-up phase. In contrast, VE changed (from pull-up to microgravity) +13 +/- 1.5 mmHg and +4.25 +/- 2.9 mmHg (upright and supine, respectively, p < .05). EU increased with microgravity +6.9 +/- .9 mmHg (upright only). LAP responses were similar, but more variable. Finally, heart chamber areas paralleled pressure changes. Thus, right and left heart filling pressure changes with sudden entry into microgravity conditions were dependent on initial circulatory volume status and somewhat modified by position (supine vs upright). |
Author | Gaffney, F.A. Fanton, J.W. Crisman, R.P. Latham, R.D. Vernalis, M.N. |
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Cites_doi | 10.1007/BF00367294 10.1152/jappl.1987.63.6.2433 10.1126/science.6729478 10.1002/j.1552-4604.1989.tb03390.x 10.1161/01.RES.63.4.798 |
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References_xml | – volume: 24 start-page: 533 year: 1981 end-page: 536 ident: BIB13 article-title: Involuntary and voluntary mechanisms for preventing cerebral eschemia due to positive (Gz) acceleration publication-title: Physiologist Suppl contributor: fullname: Code – volume: 63 start-page: 2433 year: 1987 end-page: 2437 ident: BIB4 article-title: Central venous pressure in humans during short periods of weightlessness publication-title: J Appl Physiol contributor: fullname: Johansen – volume: 30 start-page: 291 year: 1991 end-page: 298 ident: BIB7 article-title: Utilisation d'un modele primate pour l'etude des effets de stress gravitationel sur la dynamique du systeme circulatore central publication-title: Medicine Aeronautique et Spatiale contributor: fullname: Ward – start-page: 33 year: 1988 end-page: 39 ident: BIB11 article-title: Hemodynamics in primates at an early stage of adaptation to microgravity publication-title: Kosm. Biol. i Aviakosm Med. contributor: fullname: Nazin – volume: 4 start-page: 84 year: 1990 ident: BIB9 article-title: The baboon as a human surrogate to study ventricular/vascular function during conditions of altered gravitational stresses publication-title: ASGSB Bulletin contributor: fullname: Rubal – start-page: 330 year: 1977 ident: BIB6 article-title: Antropometric changes and fluid shifts publication-title: Biomedical Results from Skylab contributor: fullname: Rummel – volume: 29 start-page: 615 year: 1989 end-page: 627 ident: BIB5 article-title: Acute hemodynamic responses to weightlessness in humans publication-title: J Clin Pharmacol contributor: fullname: Burgo – start-page: 69 year: 1987 end-page: 74 ident: BIB12 article-title: Changes of blood pressure and flow in the common carotid artery in a primate flown on cosmos-1514 publication-title: Kosm. Biol. i Aviakosm Med. contributor: fullname: Stone – volume: 225 start-page: 218 year: 1984 end-page: 219 ident: BIB3 article-title: Venous pressure in man during weightlessness publication-title: Science contributor: fullname: Landry – volume: Vol 3 start-page: 1025 year: 1983 end-page: 1063 ident: BIB1 article-title: Cardiovascular adjustments to gravitational stress publication-title: Handbook of Physiology, The Cardiovascular System, Peripheral Circulation and Organ Blood Flow contributor: fullname: Stone – volume: 63 start-page: 798 year: 1988 end-page: 811 ident: BIB8 article-title: Ventricular/vascular coupling and regional arterial dynamics in the chronically hypertensive baboon: correlation with cardiovascular structural adaptation publication-title: Circulation Research contributor: fullname: Walsh – volume: 73 start-page: 447 year: 1986 end-page: 449 ident: BIB2 article-title: Venous pressure in microgravity publication-title: Naturwissen schaften contributor: fullname: Rocker – volume: Vol 3 start-page: 1025 year: 1983 ident: 10.1016/0273-1177(94)90422-7_BIB1 article-title: Cardiovascular adjustments to gravitational stress contributor: fullname: Blomqvist – volume: 73 start-page: 447 year: 1986 ident: 10.1016/0273-1177(94)90422-7_BIB2 article-title: Venous pressure in microgravity publication-title: Naturwissen schaften doi: 10.1007/BF00367294 contributor: fullname: Kirsch – start-page: 33 issue: No. 5 year: 1988 ident: 10.1016/0273-1177(94)90422-7_BIB11 article-title: Hemodynamics in primates at an early stage of adaptation to microgravity publication-title: Kosm. Biol. i Aviakosm Med. contributor: fullname: Krotov – volume: 63 start-page: 2433 issue: 6 year: 1987 ident: 10.1016/0273-1177(94)90422-7_BIB4 article-title: Central venous pressure in humans during short periods of weightlessness publication-title: J Appl Physiol doi: 10.1152/jappl.1987.63.6.2433 contributor: fullname: Norsk – volume: 225 start-page: 218 year: 1984 ident: 10.1016/0273-1177(94)90422-7_BIB3 article-title: Venous pressure in man during weightlessness publication-title: Science doi: 10.1126/science.6729478 contributor: fullname: Rocker – volume: 4 start-page: 84 issue: 1 year: 1990 ident: 10.1016/0273-1177(94)90422-7_BIB9 article-title: The baboon as a human surrogate to study ventricular/vascular function during conditions of altered gravitational stresses publication-title: ASGSB Bulletin contributor: fullname: Latham – volume: 29 start-page: 615 year: 1989 ident: 10.1016/0273-1177(94)90422-7_BIB5 article-title: Acute hemodynamic responses to weightlessness in humans publication-title: J Clin Pharmacol doi: 10.1002/j.1552-4604.1989.tb03390.x contributor: fullname: Lathers – volume: 24 start-page: 533 year: 1981 ident: 10.1016/0273-1177(94)90422-7_BIB13 article-title: Involuntary and voluntary mechanisms for preventing cerebral eschemia due to positive (Gz) acceleration publication-title: Physiologist Suppl contributor: fullname: Wood – start-page: 330 year: 1977 ident: 10.1016/0273-1177(94)90422-7_BIB6 article-title: Antropometric changes and fluid shifts contributor: fullname: Thornton – volume: 63 start-page: 798 year: 1988 ident: 10.1016/0273-1177(94)90422-7_BIB8 article-title: Ventricular/vascular coupling and regional arterial dynamics in the chronically hypertensive baboon: correlation with cardiovascular structural adaptation publication-title: Circulation Research doi: 10.1161/01.RES.63.4.798 contributor: fullname: Latham – ident: 10.1016/0273-1177(94)90422-7_BIB10 – volume: 30 start-page: 291 issue: 110 year: 1991 ident: 10.1016/0273-1177(94)90422-7_BIB7 article-title: Utilisation d'un modele primate pour l'etude des effets de stress gravitationel sur la dynamique du systeme circulatore central publication-title: Medicine Aeronautique et Spatiale contributor: fullname: Latham – start-page: 69 issue: No. 3 year: 1987 ident: 10.1016/0273-1177(94)90422-7_BIB12 article-title: Changes of blood pressure and flow in the common carotid artery in a primate flown on cosmos-1514 publication-title: Kosm. 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SubjectTerms | Animals Blood Volume - drug effects Cardiovascular Physiological Phenomena Central Venous Pressure - physiology Furosemide - pharmacology Hemodynamics - physiology Male Papio - physiology Sodium Chloride - pharmacology Space Flight Space life sciences Supine Position Weightlessness |
Title | Central hemodynamics in a baboon model during microgravity induced by parabolic flight |
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