Diversity and composition of ocular microbiota in contact lens wearers: Efficacy of liposomal ozonated oil
To characterize the ocular surface microbiota in regular contact lens wearers with dry eyes and assess the effectiveness of reducing bacterial load using a liposomal ozonated oil solution. This prospective, longitudinal, controlled study randomized subjects into two groups. Group A (45 subjects) rec...
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| Published in | Contact lens & anterior eye Vol. 48; no. 3; p. 102368 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.06.2025
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1367-0484 1476-5411 1476-5411 |
| DOI | 10.1016/j.clae.2025.102368 |
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| Abstract | To characterize the ocular surface microbiota in regular contact lens wearers with dry eyes and assess the effectiveness of reducing bacterial load using a liposomal ozonated oil solution.
This prospective, longitudinal, controlled study randomized subjects into two groups. Group A (45 subjects) received hydroxypropylmethylcellulose (HPMC, Artific®), while Group B (41 subjects) received ozonated sunflower seed oil with soybean phospholipids (OSSO, Ozonest®). Microbial communities were analyzed via DNA metabarcoding of the 16S rRNA gene, and statistical analyses (alpha and beta diversity) were performed in R.
Both groups predominantly harbored Staphylococcus caprae, Streptococcus oralis, and Corynebacterium spp., with OSSO and HPMC users showing distinct bacterial profiles. Alpha diversity showed no significant differences, but beta diversity revealed differences in bacterial composition between the groups.
The results seem to indicate that the use of ozonized oil reduces the bacterial load compared to the solution used as a control. |
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| AbstractList | To characterize the ocular surface microbiota in regular contact lens wearers with dry eyes and assess the effectiveness of reducing bacterial load using a liposomal ozonated oil solution.
This prospective, longitudinal, controlled study randomized subjects into two groups. Group A (45 subjects) received hydroxypropylmethylcellulose (HPMC, Artific®), while Group B (41 subjects) received ozonated sunflower seed oil with soybean phospholipids (OSSO, Ozonest®). Microbial communities were analyzed via DNA metabarcoding of the 16S rRNA gene, and statistical analyses (alpha and beta diversity) were performed in R.
Both groups predominantly harbored Staphylococcus caprae, Streptococcus oralis, and Corynebacterium spp., with OSSO and HPMC users showing distinct bacterial profiles. Alpha diversity showed no significant differences, but beta diversity revealed differences in bacterial composition between the groups.
The results seem to indicate that the use of ozonized oil reduces the bacterial load compared to the solution used as a control. To characterize the ocular surface microbiota in regular contact lens wearers with dry eyes and assess the effectiveness of reducing bacterial load using a liposomal ozonated oil solution.PURPOSETo characterize the ocular surface microbiota in regular contact lens wearers with dry eyes and assess the effectiveness of reducing bacterial load using a liposomal ozonated oil solution.This prospective, longitudinal, controlled study randomized subjects into two groups. Group A (45 subjects) received hydroxypropylmethylcellulose (HPMC, Artific®), while Group B (41 subjects) received ozonated sunflower seed oil with soybean phospholipids (OSSO, Ozonest®). Microbial communities were analyzed via DNA metabarcoding of the 16S rRNA gene, and statistical analyses (alpha and beta diversity) were performed in R.METHODSThis prospective, longitudinal, controlled study randomized subjects into two groups. Group A (45 subjects) received hydroxypropylmethylcellulose (HPMC, Artific®), while Group B (41 subjects) received ozonated sunflower seed oil with soybean phospholipids (OSSO, Ozonest®). Microbial communities were analyzed via DNA metabarcoding of the 16S rRNA gene, and statistical analyses (alpha and beta diversity) were performed in R.Both groups predominantly harbored Staphylococcus caprae, Streptococcus oralis, and Corynebacterium spp., with OSSO and HPMC users showing distinct bacterial profiles. Alpha diversity showed no significant differences, but beta diversity revealed differences in bacterial composition between the groups.RESULTSBoth groups predominantly harbored Staphylococcus caprae, Streptococcus oralis, and Corynebacterium spp., with OSSO and HPMC users showing distinct bacterial profiles. Alpha diversity showed no significant differences, but beta diversity revealed differences in bacterial composition between the groups.The results seem to indicate that the use of ozonized oil reduces the bacterial load compared to the solution used as a control.CONCLUSIONSThe results seem to indicate that the use of ozonized oil reduces the bacterial load compared to the solution used as a control. |
| ArticleNumber | 102368 |
| Author | De-Hita-Cantalejo, Concepción Gallardo-Real, Inmaculada Capote-Puente, Raúl Sánchez-González, María Carmen Sánchez-González, José-María Gutiérrez-Sánchez, Estanislao |
| Author_xml | – sequence: 1 givenname: María Carmen surname: Sánchez-González fullname: Sánchez-González, María Carmen email: msanchez77@us.es organization: Department of Physics of Condensed Matter, Optics Area, University of Seville, Reina Mercedes S/N, 41012 Seville, Spain – sequence: 2 givenname: Inmaculada surname: Gallardo-Real fullname: Gallardo-Real, Inmaculada organization: Department of Physics of Condensed Matter, Optics Area, University of Seville, Reina Mercedes S/N, 41012 Seville, Spain – sequence: 3 givenname: Estanislao surname: Gutiérrez-Sánchez fullname: Gutiérrez-Sánchez, Estanislao organization: Department of Surgery, Ophthalmology Area, University of Seville, Doctor Fedriani S/N, 41009, Seville, Spain – sequence: 4 givenname: Concepción surname: De-Hita-Cantalejo fullname: De-Hita-Cantalejo, Concepción organization: Department of Physics of Condensed Matter, Optics Area, University of Seville, Reina Mercedes S/N, 41012 Seville, Spain – sequence: 5 givenname: Raúl surname: Capote-Puente fullname: Capote-Puente, Raúl organization: Department of Physics of Condensed Matter, Optics Area, University of Seville, Reina Mercedes S/N, 41012 Seville, Spain – sequence: 6 givenname: José-María surname: Sánchez-González fullname: Sánchez-González, José-María organization: Department of Physics of Condensed Matter, Optics Area, University of Seville, Reina Mercedes S/N, 41012 Seville, Spain |
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| Cites_doi | 10.1016/j.clae.2016.04.005 10.1186/s12348-021-00238-2 10.1097/j.jcrs.0000000000000672 10.1016/j.exer.2022.109080 10.1038/s41467-019-12669-6 10.1038/s41598-017-10494-9 10.1139/gen-2017-0081 10.1016/j.exer.2013.06.003 10.1186/s12886-017-0612-2 10.1097/OPX.0b013e318269c90d 10.2147/OPTH.S360929 10.1128/mBio.00198-16 10.1128/AEM.00712-07 10.1093/mmy/myac055 10.1038/s41592-018-0141-9 10.1016/j.survophthal.2021.03.010 10.1021/acsinfecdis.7b00170 10.1046/j.1461-0248.2001.00230.x 10.1097/j.jcrs.0000000000000754 10.3390/ijms241814078 10.1097/ACI.0b013e3283303e1b 10.1016/j.exer.2019.107848 10.1111/1751-7915.13949 10.1038/nmeth.3869 10.1016/j.ajo.2014.06.014 10.3390/ijms231810229 10.2147/OPTH.S5778 10.1016/j.exer.2018.10.006 10.1046/j.1365-2672.2001.01235.x 10.1167/iovs.18-24845 10.22336/rjo.2020.42 10.1016/j.jtos.2017.05.001 10.1177/11206721221149077 10.1038/s41587-019-0209-9 10.1097/ICO.0000000000000682 10.1111/j.1365-2133.2005.06939.x 10.1159/000488846 10.1177/1535370218813616 10.32614/CRAN.package.ggpubr 10.1007/s00417-021-05361-3 10.1080/02713683.2019.1570526 10.3390/jcm12196354 |
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| Keywords | Ozone Dry Eye Microbiome ocular Ozonated Sunflower Seed Oil |
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| References | ElKitkat, Ebeid, Habib, Shoukry (b0260) 2016; 35 Herlemann, Geissinger, Brune (b0145) 2007; 73 Kaehler, Bokulich, McDonald, Knight, Caporaso, Huttley (b0170) 2019; 10 Marchegiani, Magagnini, Cerquetella, Troiano, Franchini, Franchini (b0210) 2019; 189 Zegans, Van Gelder (b0025) 2014; 158 Kassambara A. “ggplot2” Based Publication Ready Plots [R package ggpubr version 0.6.0] 2023. Gotelli, Colwell (b0250) 2001; 4 Parekh, Borroni, Romano, Kaye, Camposampiero, Di (b0040) 2019; 4 Introduction to the microbiome R package n.d. Gonzalez, Navas-Molina, Kosciolek, McDonald, Vázquez-Baeza, Ackermann (b0175) 2018; 15 Valacchi, Fortino, Bocci (b0105) 2005; 153 Chao, Akileswaran, Bailey, Willcox, Van Gelder, Lakkis (b0125) 2018; 59 Spadea, Zanotto, Cavallo, Campagna, Giannico, Costagliola (b0225) 2021; 47 (accessed September 16, 2024). ( Gentili, Strazzabosco, Salgari, Mancini, Rizzo, Beltrami (b0240) 2023; 24 Ayehubizu, Mulu, Biadglegne (b0070) 2021; 11 Sechi, Lezcano, Nunez, Espim, Duprè, Pinna (b0100) 2001; 90 . Wolfmeier, Pletzer, Mansour, Hancock (b0245) 2018; 4 Schiano-Lomoriello, Abicca, Contento, Gabrielli, Alfonsi, Di Pietro (b0215) 2024; 14 Borroni, Bonzano, Sánchez-González, Rachwani-Anil, Zamorano-Martín, Pereza-Nieves (b0035) 2023; 33 Miller, Iovieno (b0045) 2009; 9 Shin, Price, Albert, Dodick, Park, Dominguez-Belloa (b0050) 2016; 7 Baim, Movahedan, Farooq, Skondra (b0110) 2019; 244 Aragona, Baudouin, Benitez del Castillo, Messmer, Barabino, Merayo-Lloves (b0120) 2021; 66 Callahan, McMurdie, Rosen, Han, Johnson, Holmes (b0160) 2016; 13 Passidomo, Pignatelli, Addabbo, Costagliola (b0090) 2021; 14 Paduch, Urbanik-Sypniewska, Kutkowska, Chorągiewicz, Matysik-Woźniak, Zweifel (b0085) 2021; 10 Buscar con Google n.d. Pérez-Santonja, Güell, Gris, Dorrego, Pellicer, Benítez-Del-castillo (b0220) 2022; 16 Spadea, Tonti, Spaterna, Marchegiani (b0080) 2018; 9 Pal, Vani, Shivaji, Donthineni, Basu, Arunasri (b0265) 2022; 219 Illumina | Sequencing and array solutions to fuel genomic discoveries n.d. Dor, Eperon, Lalive, Guex-Crosier, Hamedani, Salvisberg (b0005) 2019; 179 Higa, Cintra, Álvarez, Ribeiro, Ferreira, Tavares (b0235) 2022; 60 Wolffsohn, Arita, Chalmers, Djalilian, Dogru, Dumbleton (b0140) 2017; 15 Borroni, Paytuví-Gallart, Sanseverino, Gómez-Huertas, Bonci, Romano (b0015) 2022; 23 Zerillo, Polvere, Varricchio, Madera, D’Andrea, Voccola (b0230) 2022; 15 Rocha-de-Lossada, Mazzotta, Gabrielli, Papa, Gómez-Huertas, García-López (b0020) 2023; 12 Teweldemedhin, Gebreyesus, Atsbaha, Asgedom, Saravanan (b0060) 2017; 17 Chalmers, Begley, Moody, Hickson-Curran (b0135) 2012; 89 Ozkan, Nielsen, Diez-Vives, Coroneo, Thomas, Willcox (b0055) 2017; 7 Bolyen, Rideout, Dillon, Bokulich, Abnet, Al-Ghalith (b0155) 2019; 37 Tognetto, Pastore, Guerin, Decorti, Franzin, Lagatolla (b0075) 2022; 260 Vierna, Doña, Vizcaíno, Serrano, Jovani, Chain (b0150) 2017; 60 Bertino (b0065) 2009; 3 Quast, Pruesse, Yilmaz, Gerken, Schweer, Yarza (b0165) 2013; 41 Chalmers, Keay, Hickson-Curran, Gleason (b0130) 2016; 39 Ayehubizu, Mulu, Biadglegne (b0205) 2021; 11 Victoria, Balș, Aramă (b0200) 2020; 64 Kanclerz, Myers (b0255) 2022; 48 Willcox (b0030) 2013; 117 Benítez-Del-Castillo (b0095) 2023 Ozkan, Willcox (b0115) 2019; 44 Borroni, Romano, Kaye, Somerville, Napoli, Fasolo (b0010) 2019; 4 Pal (10.1016/j.clae.2025.102368_b0265) 2022; 219 Zerillo (10.1016/j.clae.2025.102368_b0230) 2022; 15 Spadea (10.1016/j.clae.2025.102368_b0080) 2018; 9 Wolffsohn (10.1016/j.clae.2025.102368_b0140) 2017; 15 Quast (10.1016/j.clae.2025.102368_b0165) 2013; 41 Valacchi (10.1016/j.clae.2025.102368_b0105) 2005; 153 Chalmers (10.1016/j.clae.2025.102368_b0130) 2016; 39 Zegans (10.1016/j.clae.2025.102368_b0025) 2014; 158 Ozkan (10.1016/j.clae.2025.102368_b0115) 2019; 44 Rocha-de-Lossada (10.1016/j.clae.2025.102368_b0020) 2023; 12 Parekh (10.1016/j.clae.2025.102368_b0040) 2019; 4 Higa (10.1016/j.clae.2025.102368_b0235) 2022; 60 Bertino (10.1016/j.clae.2025.102368_b0065) 2009; 3 Passidomo (10.1016/j.clae.2025.102368_b0090) 2021; 14 Kanclerz (10.1016/j.clae.2025.102368_b0255) 2022; 48 Willcox (10.1016/j.clae.2025.102368_b0030) 2013; 117 Borroni (10.1016/j.clae.2025.102368_b0010) 2019; 4 Borroni (10.1016/j.clae.2025.102368_b0015) 2022; 23 Chao (10.1016/j.clae.2025.102368_b0125) 2018; 59 Marchegiani (10.1016/j.clae.2025.102368_b0210) 2019; 189 Wolfmeier (10.1016/j.clae.2025.102368_b0245) 2018; 4 Sechi (10.1016/j.clae.2025.102368_b0100) 2001; 90 Gotelli (10.1016/j.clae.2025.102368_b0250) 2001; 4 Ozkan (10.1016/j.clae.2025.102368_b0055) 2017; 7 Miller (10.1016/j.clae.2025.102368_b0045) 2009; 9 Spadea (10.1016/j.clae.2025.102368_b0225) 2021; 47 Ayehubizu (10.1016/j.clae.2025.102368_b0070) 2021; 11 Herlemann (10.1016/j.clae.2025.102368_b0145) 2007; 73 Tognetto (10.1016/j.clae.2025.102368_b0075) 2022; 260 Baim (10.1016/j.clae.2025.102368_b0110) 2019; 244 Kaehler (10.1016/j.clae.2025.102368_b0170) 2019; 10 Pérez-Santonja (10.1016/j.clae.2025.102368_b0220) 2022; 16 Ayehubizu (10.1016/j.clae.2025.102368_b0205) 2021; 11 10.1016/j.clae.2025.102368_b0185 Paduch (10.1016/j.clae.2025.102368_b0085) 2021; 10 Vierna (10.1016/j.clae.2025.102368_b0150) 2017; 60 Gonzalez (10.1016/j.clae.2025.102368_b0175) 2018; 15 10.1016/j.clae.2025.102368_b0180 Bolyen (10.1016/j.clae.2025.102368_b0155) 2019; 37 Callahan (10.1016/j.clae.2025.102368_b0160) 2016; 13 Borroni (10.1016/j.clae.2025.102368_b0035) 2023; 33 Benítez-Del-Castillo (10.1016/j.clae.2025.102368_b0095) 2023 Shin (10.1016/j.clae.2025.102368_b0050) 2016; 7 Dor (10.1016/j.clae.2025.102368_b0005) 2019; 179 Teweldemedhin (10.1016/j.clae.2025.102368_b0060) 2017; 17 Chalmers (10.1016/j.clae.2025.102368_b0135) 2012; 89 ElKitkat (10.1016/j.clae.2025.102368_b0260) 2016; 35 Gentili (10.1016/j.clae.2025.102368_b0240) 2023; 24 Aragona (10.1016/j.clae.2025.102368_b0120) 2021; 66 Victoria (10.1016/j.clae.2025.102368_b0200) 2020; 64 10.1016/j.clae.2025.102368_b0195 10.1016/j.clae.2025.102368_b0190 Schiano-Lomoriello (10.1016/j.clae.2025.102368_b0215) 2024; 14 |
| References_xml | – volume: 11 start-page: 1 year: 2021 end-page: 10 ident: b0070 article-title: Common bacterial causes of external ocular infections, associated risk factors and antibiotic resistance among patients at ophthalmology unit of Felege Hiwot Referral Hospital, Northwest Ethiopia: a cross-sectional study publication-title: J Ophthalmic Inflamm Infect – volume: 260 start-page: 289 year: 2022 end-page: 293 ident: b0075 article-title: Bactericidal activity of three different antiseptic ophthalmic preparations as surgical prophylaxis publication-title: Graefes Arch Clin Exp Ophthalmol – volume: 41 year: 2013 ident: b0165 article-title: The SILVA ribosomal RNA gene database project: improved data processing and web-based tools publication-title: Nucleic Acids Res – volume: 23 year: 2022 ident: b0015 article-title: Exploring the healthy eye microbiota niche in a multicenter study publication-title: Int J Mol Sci – volume: 10 year: 2019 ident: b0170 article-title: Species abundance information improves sequence taxonomy classification accuracy publication-title: Nat Commun – volume: 4 start-page: 93 year: 2018 end-page: 106 ident: b0245 article-title: New Perspectives in Biofilm Eradication publication-title: ACS Infect Dis – volume: 179 start-page: 64 year: 2019 end-page: 74 ident: b0005 article-title: Investigation of the global protein content from healthy human tears publication-title: Exp Eye Res – reference: ( – reference: Illumina | Sequencing and array solutions to fuel genomic discoveries n.d. – volume: 9 start-page: 466 year: 2009 end-page: 470 ident: b0045 article-title: The role of microbial flora on the ocular surface publication-title: Curr Opin Allergy Clin Immunol – volume: 15 start-page: 1422 year: 2022 end-page: 1433 ident: b0230 article-title: Antibiofilm and repair activity of ozonated oil in liposome publication-title: Microb Biotechnol – reference: ). - Buscar con Google n.d. – volume: 4 year: 2019 ident: b0010 article-title: Metagenomics in ophthalmology: Current findings and future prospectives publication-title: BMJ Open Ophthalmol – volume: 153 start-page: 1096 year: 2005 end-page: 1100 ident: b0105 article-title: The dual action of ozone on the skin publication-title: Br J Dermatol – volume: 13 start-page: 581 year: 2016 end-page: 583 ident: b0160 article-title: DADA2: High-resolution sample inference from Illumina amplicon data publication-title: Nat Methods – volume: 15 start-page: 796 year: 2018 end-page: 798 ident: b0175 article-title: Qiita: Rapid, web-enabled microbiome meta-analysis publication-title: Nat Methods – volume: 89 start-page: 1435 year: 2012 end-page: 1442 ident: b0135 article-title: Contact Lens Dry Eye Questionnaire-8 (CLDEQ-8) and opinion of contact lens performance publication-title: Optom vis Sci – volume: 47 start-page: 1548 year: 2021 end-page: 1555 ident: b0225 article-title: Effectiveness of liposomal ozonized oil in reducing ocular microbial flora in patients undergoing cataract surgery publication-title: J Cataract Refract Surg – volume: 66 start-page: 907 year: 2021 end-page: 925 ident: b0120 article-title: The ocular microbiome and microbiota and their effects on ocular surface pathophysiology and disorders publication-title: Surv Ophthalmol – volume: 39 start-page: 342 year: 2016 end-page: 352 ident: b0130 article-title: Cutoff score and responsiveness of the 8-item Contact Lens Dry Eye Questionnaire (CLDEQ-8) in a Large daily disposable contact lens registry publication-title: Contact Lens Anterior Eye – volume: 33 start-page: 1589 year: 2023 end-page: 1595 ident: b0035 article-title: Shotgun metagenomic sequencing in culture negative microbial keratitis publication-title: Eur J Ophthalmol – volume: 35 start-page: 72 year: 2016 end-page: 76 ident: b0260 article-title: Safety of intracameral injection of minimal bactericidal concentration of povidone iodine on the corneal endothelium in a rabbit model publication-title: Cornea – volume: 14 start-page: 389 year: 2024 ident: b0215 article-title: Infectious Keratitis: Characterization of Microbial Diversity through Species Richness and Shannon Diversity Index publication-title: Biomol – volume: 60 year: 2022 ident: b0235 article-title: Ozonated oil is effective at killing Candida species and Streptococcus mutans biofilm-derived cells under aerobic and microaerobic conditions publication-title: Med Mycol – volume: 60 start-page: 868 year: 2017 end-page: 873 ident: b0150 article-title: PCR cycles above routine numbers do not compromise high-throughput DNA barcoding results publication-title: Genome – volume: 244 start-page: 419 year: 2019 end-page: 429 ident: b0110 article-title: The microbiome and ophthalmic disease publication-title: Exp Biol Med – volume: 48 start-page: 363 year: 2022 end-page: 369 ident: b0255 article-title: Chlorhexidine and other alternatives for povidone-iodine in ophthalmic surgery: Review of comparative studies publication-title: J Cataract Refract Surg – volume: 73 start-page: 6682 year: 2007 end-page: 6685 ident: b0145 article-title: The termite group I phylum is highly diverse and widespread in the environment publication-title: Appl Environ Microbiol – volume: 7 start-page: 9880 year: 2017 ident: b0055 article-title: Temporal stability and composition of the ocular surface microbiome publication-title: Sci Rep – reference: (accessed September 16, 2024). – year: 2023 ident: b0095 article-title: Liposomal ozonated oil effectiveness in the signs and symptoms of blepharitis in usual clinical practice publication-title: Eur J Ophthalmol – volume: 189 year: 2019 ident: b0210 article-title: Preoperative topical liposomal ozone dispersion to reduce bacterial colonization in conjunctival sac and periocular skin: Preliminary study in dogs publication-title: Exp Eye Res – volume: 14 start-page: 327 year: 2021 end-page: 332 ident: b0090 article-title: Topical Liposomal Ozonated Oil in Complicated Corneal Disease: A Report on Three Clinical Cases publication-title: Int Med Case Rep J – volume: 158 start-page: 420 year: 2014 end-page: 422 ident: b0025 article-title: Considerations in understanding the ocular surface microbiome publication-title: Am J Ophthalmol – volume: 12 year: 2023 ident: b0020 article-title: Ocular surface microbiota in naïve keratoconus: A multicenter validation study publication-title: J Clin Med – volume: 44 year: 2019 ident: b0115 article-title: The ocular microbiome: molecular characterisation of a unique and low microbial environment publication-title: Curr Eye Res – volume: 17 year: 2017 ident: b0060 article-title: Bacterial profile of ocular infections: a systematic review publication-title: BMC Ophthalmol – volume: 10 year: 2021 ident: b0085 article-title: Ozone-based eye drops activity on ocular epithelial cells and potential pathogens infecting the front of the eye publication-title: Antioxidants (basel, Switzerland) – volume: 117 start-page: 99 year: 2013 end-page: 105 ident: b0030 article-title: Characterization of the normal microbiota of the ocular surface publication-title: Exp Eye Res – volume: 59 start-page: 5752 year: 2018 end-page: 5761 ident: b0125 article-title: Potential role of ocular microbiome, host genotype, tear cytokines, and environmental factors in corneal infiltrative events in contact lens wearers publication-title: Invest Ophthalmol vis Sci – volume: 219 year: 2022 ident: b0265 article-title: Characterising the tear bacterial microbiome in young adults publication-title: Exp Eye Res – reference: . (accessed September 16, 2024). – volume: 64 start-page: 245 year: 2020 ident: b0200 article-title: Topical antibiotic therapy in eye infections - myths and certainties in the era of bacterial resistance to antibiotics publication-title: Rom J Ophthalmol – volume: 37 start-page: 852 year: 2019 end-page: 857 ident: b0155 article-title: Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2 publication-title: Nat Biotechnol – volume: 90 start-page: 279 year: 2001 end-page: 284 ident: b0100 article-title: Antibacterial activity of ozonized sunflower oil (Oleozon) publication-title: J Appl Microbiol – volume: 16 start-page: 1953 year: 2022 end-page: 1962 ident: b0220 article-title: Liposomal ozonated oil in ocular infections: A review of preclinical and clinical studies, focusing on its antiseptic and regenerative properties publication-title: Clin Ophthalmol – volume: 3 start-page: 507 year: 2009 end-page: 521 ident: b0065 article-title: Impact of antibiotic resistance in the management of ocular infections: the role of current and future antibiotics publication-title: Clin Ophthalmol – volume: 4 start-page: 379 year: 2001 end-page: 391 ident: b0250 article-title: Quantifying biodiversity: procedures and pitfalls in the measurement and comparison of species richness publication-title: Ecol Lett – reference: . – volume: 11 year: 2021 ident: b0205 article-title: Common bacterial causes of external ocular infections, associated risk factors and antibiotic resistance among patients at ophthalmology unit of Felege Hiwot Referral Hospital, Northwest Ethiopia: a cross-sectional study publication-title: J Ophthalmic Inflamm Infect – volume: 24 year: 2023 ident: b0240 article-title: Ozonated oil in liposome eyedrops reduces the formation of biofilm, selection of antibiotic-resistant bacteria, and adhesion of bacteria to human corneal cells publication-title: Int J Mol Sci – volume: 7 year: 2016 ident: b0050 article-title: Changes in the eye microbiota associated with contact lens wearing publication-title: MBio – volume: 9 start-page: 287 year: 2018 end-page: 298 ident: b0080 article-title: Use of ozone-based eye drops: A series of cases in veterinary and human spontaneous ocular pathologies publication-title: Case Rep Ophthalmol – reference: Kassambara A. “ggplot2” Based Publication Ready Plots [R package ggpubr version 0.6.0] 2023. – volume: 15 start-page: 539 year: 2017 end-page: 574 ident: b0140 article-title: TFOS DEWS II Diagnostic Methodology report publication-title: Ocul Surf – volume: 4 year: 2019 ident: b0040 article-title: Next-generation sequencing for the detection of microorganisms present in human donor corneal preservation medium publication-title: BMJ Open Ophthalmol – reference: Introduction to the microbiome R package n.d. – ident: 10.1016/j.clae.2025.102368_b0185 – volume: 39 start-page: 342 year: 2016 ident: 10.1016/j.clae.2025.102368_b0130 article-title: Cutoff score and responsiveness of the 8-item Contact Lens Dry Eye Questionnaire (CLDEQ-8) in a Large daily disposable contact lens registry publication-title: Contact Lens Anterior Eye doi: 10.1016/j.clae.2016.04.005 – volume: 11 start-page: 1 year: 2021 ident: 10.1016/j.clae.2025.102368_b0070 article-title: Common bacterial causes of external ocular infections, associated risk factors and antibiotic resistance among patients at ophthalmology unit of Felege Hiwot Referral Hospital, Northwest Ethiopia: a cross-sectional study publication-title: J Ophthalmic Inflamm Infect doi: 10.1186/s12348-021-00238-2 – volume: 47 start-page: 1548 year: 2021 ident: 10.1016/j.clae.2025.102368_b0225 article-title: Effectiveness of liposomal ozonized oil in reducing ocular microbial flora in patients undergoing cataract surgery publication-title: J Cataract Refract Surg doi: 10.1097/j.jcrs.0000000000000672 – volume: 219 year: 2022 ident: 10.1016/j.clae.2025.102368_b0265 article-title: Characterising the tear bacterial microbiome in young adults publication-title: Exp Eye Res doi: 10.1016/j.exer.2022.109080 – volume: 10 year: 2019 ident: 10.1016/j.clae.2025.102368_b0170 article-title: Species abundance information improves sequence taxonomy classification accuracy publication-title: Nat Commun doi: 10.1038/s41467-019-12669-6 – volume: 7 start-page: 9880 year: 2017 ident: 10.1016/j.clae.2025.102368_b0055 article-title: Temporal stability and composition of the ocular surface microbiome publication-title: Sci Rep doi: 10.1038/s41598-017-10494-9 – volume: 60 start-page: 868 year: 2017 ident: 10.1016/j.clae.2025.102368_b0150 article-title: PCR cycles above routine numbers do not compromise high-throughput DNA barcoding results publication-title: Genome doi: 10.1139/gen-2017-0081 – volume: 117 start-page: 99 year: 2013 ident: 10.1016/j.clae.2025.102368_b0030 article-title: Characterization of the normal microbiota of the ocular surface publication-title: Exp Eye Res doi: 10.1016/j.exer.2013.06.003 – volume: 17 year: 2017 ident: 10.1016/j.clae.2025.102368_b0060 article-title: Bacterial profile of ocular infections: a systematic review publication-title: BMC Ophthalmol doi: 10.1186/s12886-017-0612-2 – volume: 89 start-page: 1435 year: 2012 ident: 10.1016/j.clae.2025.102368_b0135 article-title: Contact Lens Dry Eye Questionnaire-8 (CLDEQ-8) and opinion of contact lens performance publication-title: Optom vis Sci doi: 10.1097/OPX.0b013e318269c90d – volume: 16 start-page: 1953 year: 2022 ident: 10.1016/j.clae.2025.102368_b0220 article-title: Liposomal ozonated oil in ocular infections: A review of preclinical and clinical studies, focusing on its antiseptic and regenerative properties publication-title: Clin Ophthalmol doi: 10.2147/OPTH.S360929 – volume: 7 year: 2016 ident: 10.1016/j.clae.2025.102368_b0050 article-title: Changes in the eye microbiota associated with contact lens wearing publication-title: MBio doi: 10.1128/mBio.00198-16 – volume: 73 start-page: 6682 year: 2007 ident: 10.1016/j.clae.2025.102368_b0145 article-title: The termite group I phylum is highly diverse and widespread in the environment publication-title: Appl Environ Microbiol doi: 10.1128/AEM.00712-07 – volume: 60 year: 2022 ident: 10.1016/j.clae.2025.102368_b0235 article-title: Ozonated oil is effective at killing Candida species and Streptococcus mutans biofilm-derived cells under aerobic and microaerobic conditions publication-title: Med Mycol doi: 10.1093/mmy/myac055 – volume: 15 start-page: 796 year: 2018 ident: 10.1016/j.clae.2025.102368_b0175 article-title: Qiita: Rapid, web-enabled microbiome meta-analysis publication-title: Nat Methods doi: 10.1038/s41592-018-0141-9 – volume: 66 start-page: 907 year: 2021 ident: 10.1016/j.clae.2025.102368_b0120 article-title: The ocular microbiome and microbiota and their effects on ocular surface pathophysiology and disorders publication-title: Surv Ophthalmol doi: 10.1016/j.survophthal.2021.03.010 – volume: 4 start-page: 93 year: 2018 ident: 10.1016/j.clae.2025.102368_b0245 article-title: New Perspectives in Biofilm Eradication publication-title: ACS Infect Dis doi: 10.1021/acsinfecdis.7b00170 – volume: 4 year: 2019 ident: 10.1016/j.clae.2025.102368_b0010 article-title: Metagenomics in ophthalmology: Current findings and future prospectives publication-title: BMJ Open Ophthalmol – volume: 4 start-page: 379 year: 2001 ident: 10.1016/j.clae.2025.102368_b0250 article-title: Quantifying biodiversity: procedures and pitfalls in the measurement and comparison of species richness publication-title: Ecol Lett doi: 10.1046/j.1461-0248.2001.00230.x – volume: 48 start-page: 363 year: 2022 ident: 10.1016/j.clae.2025.102368_b0255 article-title: Chlorhexidine and other alternatives for povidone-iodine in ophthalmic surgery: Review of comparative studies publication-title: J Cataract Refract Surg doi: 10.1097/j.jcrs.0000000000000754 – volume: 10 year: 2021 ident: 10.1016/j.clae.2025.102368_b0085 article-title: Ozone-based eye drops activity on ocular epithelial cells and potential pathogens infecting the front of the eye publication-title: Antioxidants (basel, Switzerland) – volume: 24 year: 2023 ident: 10.1016/j.clae.2025.102368_b0240 article-title: Ozonated oil in liposome eyedrops reduces the formation of biofilm, selection of antibiotic-resistant bacteria, and adhesion of bacteria to human corneal cells publication-title: Int J Mol Sci doi: 10.3390/ijms241814078 – volume: 9 start-page: 466 year: 2009 ident: 10.1016/j.clae.2025.102368_b0045 article-title: The role of microbial flora on the ocular surface publication-title: Curr Opin Allergy Clin Immunol doi: 10.1097/ACI.0b013e3283303e1b – volume: 189 year: 2019 ident: 10.1016/j.clae.2025.102368_b0210 article-title: Preoperative topical liposomal ozone dispersion to reduce bacterial colonization in conjunctival sac and periocular skin: Preliminary study in dogs publication-title: Exp Eye Res doi: 10.1016/j.exer.2019.107848 – volume: 15 start-page: 1422 year: 2022 ident: 10.1016/j.clae.2025.102368_b0230 article-title: Antibiofilm and repair activity of ozonated oil in liposome publication-title: Microb Biotechnol doi: 10.1111/1751-7915.13949 – year: 2023 ident: 10.1016/j.clae.2025.102368_b0095 article-title: Liposomal ozonated oil effectiveness in the signs and symptoms of blepharitis in usual clinical practice publication-title: Eur J Ophthalmol – volume: 13 start-page: 581 year: 2016 ident: 10.1016/j.clae.2025.102368_b0160 article-title: DADA2: High-resolution sample inference from Illumina amplicon data publication-title: Nat Methods doi: 10.1038/nmeth.3869 – volume: 14 start-page: 389 year: 2024 ident: 10.1016/j.clae.2025.102368_b0215 article-title: Infectious Keratitis: Characterization of Microbial Diversity through Species Richness and Shannon Diversity Index publication-title: Biomol – volume: 158 start-page: 420 year: 2014 ident: 10.1016/j.clae.2025.102368_b0025 article-title: Considerations in understanding the ocular surface microbiome publication-title: Am J Ophthalmol doi: 10.1016/j.ajo.2014.06.014 – volume: 41 year: 2013 ident: 10.1016/j.clae.2025.102368_b0165 article-title: The SILVA ribosomal RNA gene database project: improved data processing and web-based tools publication-title: Nucleic Acids Res – volume: 23 year: 2022 ident: 10.1016/j.clae.2025.102368_b0015 article-title: Exploring the healthy eye microbiota niche in a multicenter study publication-title: Int J Mol Sci doi: 10.3390/ijms231810229 – volume: 3 start-page: 507 year: 2009 ident: 10.1016/j.clae.2025.102368_b0065 article-title: Impact of antibiotic resistance in the management of ocular infections: the role of current and future antibiotics publication-title: Clin Ophthalmol doi: 10.2147/OPTH.S5778 – volume: 179 start-page: 64 year: 2019 ident: 10.1016/j.clae.2025.102368_b0005 article-title: Investigation of the global protein content from healthy human tears publication-title: Exp Eye Res doi: 10.1016/j.exer.2018.10.006 – volume: 90 start-page: 279 year: 2001 ident: 10.1016/j.clae.2025.102368_b0100 article-title: Antibacterial activity of ozonized sunflower oil (Oleozon) publication-title: J Appl Microbiol doi: 10.1046/j.1365-2672.2001.01235.x – ident: 10.1016/j.clae.2025.102368_b0180 – volume: 4 year: 2019 ident: 10.1016/j.clae.2025.102368_b0040 article-title: Next-generation sequencing for the detection of microorganisms present in human donor corneal preservation medium publication-title: BMJ Open Ophthalmol – volume: 59 start-page: 5752 year: 2018 ident: 10.1016/j.clae.2025.102368_b0125 article-title: Potential role of ocular microbiome, host genotype, tear cytokines, and environmental factors in corneal infiltrative events in contact lens wearers publication-title: Invest Ophthalmol vis Sci doi: 10.1167/iovs.18-24845 – volume: 64 start-page: 245 year: 2020 ident: 10.1016/j.clae.2025.102368_b0200 article-title: Topical antibiotic therapy in eye infections - myths and certainties in the era of bacterial resistance to antibiotics publication-title: Rom J Ophthalmol doi: 10.22336/rjo.2020.42 – volume: 15 start-page: 539 year: 2017 ident: 10.1016/j.clae.2025.102368_b0140 article-title: TFOS DEWS II Diagnostic Methodology report publication-title: Ocul Surf doi: 10.1016/j.jtos.2017.05.001 – volume: 11 year: 2021 ident: 10.1016/j.clae.2025.102368_b0205 article-title: Common bacterial causes of external ocular infections, associated risk factors and antibiotic resistance among patients at ophthalmology unit of Felege Hiwot Referral Hospital, Northwest Ethiopia: a cross-sectional study publication-title: J Ophthalmic Inflamm Infect doi: 10.1186/s12348-021-00238-2 – volume: 33 start-page: 1589 year: 2023 ident: 10.1016/j.clae.2025.102368_b0035 article-title: Shotgun metagenomic sequencing in culture negative microbial keratitis publication-title: Eur J Ophthalmol doi: 10.1177/11206721221149077 – volume: 37 start-page: 852 year: 2019 ident: 10.1016/j.clae.2025.102368_b0155 article-title: Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2 publication-title: Nat Biotechnol doi: 10.1038/s41587-019-0209-9 – volume: 35 start-page: 72 year: 2016 ident: 10.1016/j.clae.2025.102368_b0260 article-title: Safety of intracameral injection of minimal bactericidal concentration of povidone iodine on the corneal endothelium in a rabbit model publication-title: Cornea doi: 10.1097/ICO.0000000000000682 – volume: 153 start-page: 1096 year: 2005 ident: 10.1016/j.clae.2025.102368_b0105 article-title: The dual action of ozone on the skin publication-title: Br J Dermatol doi: 10.1111/j.1365-2133.2005.06939.x – volume: 14 start-page: 327 year: 2021 ident: 10.1016/j.clae.2025.102368_b0090 article-title: Topical Liposomal Ozonated Oil in Complicated Corneal Disease: A Report on Three Clinical Cases publication-title: Int Med Case Rep J – volume: 9 start-page: 287 year: 2018 ident: 10.1016/j.clae.2025.102368_b0080 article-title: Use of ozone-based eye drops: A series of cases in veterinary and human spontaneous ocular pathologies publication-title: Case Rep Ophthalmol doi: 10.1159/000488846 – volume: 244 start-page: 419 year: 2019 ident: 10.1016/j.clae.2025.102368_b0110 article-title: The microbiome and ophthalmic disease publication-title: Exp Biol Med doi: 10.1177/1535370218813616 – ident: 10.1016/j.clae.2025.102368_b0190 doi: 10.32614/CRAN.package.ggpubr – volume: 260 start-page: 289 year: 2022 ident: 10.1016/j.clae.2025.102368_b0075 article-title: Bactericidal activity of three different antiseptic ophthalmic preparations as surgical prophylaxis publication-title: Graefes Arch Clin Exp Ophthalmol doi: 10.1007/s00417-021-05361-3 – ident: 10.1016/j.clae.2025.102368_b0195 – volume: 44 year: 2019 ident: 10.1016/j.clae.2025.102368_b0115 article-title: The ocular microbiome: molecular characterisation of a unique and low microbial environment publication-title: Curr Eye Res doi: 10.1080/02713683.2019.1570526 – volume: 12 year: 2023 ident: 10.1016/j.clae.2025.102368_b0020 article-title: Ocular surface microbiota in naïve keratoconus: A multicenter validation study publication-title: J Clin Med doi: 10.3390/jcm12196354 |
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| SubjectTerms | Adult Bacteria - genetics Bacteria - isolation & purification Bacterial Load Contact Lens Solutions Dry Eye Dry Eye Syndromes - drug therapy Dry Eye Syndromes - microbiology Female Humans Liposomes Male Microbiome ocular Microbiota - drug effects Middle Aged Ozonated Sunflower Seed Oil Ozone Ozone - administration & dosage Prospective Studies RNA, Ribosomal, 16S - genetics Sunflower Oil - administration & dosage Young Adult |
| Title | Diversity and composition of ocular microbiota in contact lens wearers: Efficacy of liposomal ozonated oil |
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