Subcortical Brain Alterations in Carriers of Genomic Copy Number Variants

• Published in: The American journal of psychiatry Vol. 180; no. 9; pp. 685 - 698
• Main Authors: Kumar, Kuldeep, Modenato, Claudia, Moreau, Clara, Ching, Christopher R.K., Harvey, Annabelle, Martin-Brevet, Sandra, Huguet, Guillaume, Jean-Louis, Martineau, Douard, Elise, Martin, Charles-Olivier, Younis, Nadine, Tamer, Petra, Maillard, Anne M., Rodriguez-Herreros, Borja, Pain, Aurélie, Kushan, Leila, Isaev, Dmitry, Alpert, Kathryn, Ragothaman, Anjani, Turner, Jessica A., Wang, Lei, Ho, Tiffany C., Schmaal, Lianne, Silva, Ana I., van den Bree, Marianne B.M., Linden, David E.J., Owen, Michael J., Hall, Jeremy, Lippé, Sarah, Dumas, Guillaume, Draganski, Bogdan, Gutman, Boris A., Sønderby, Ida E., Andreassen, Ole A., Schultz, Laura M., Almasy, Laura, Glahn, David C., Bearden, Carrie E., Thompson, Paul M., Jacquemont, Sébastien
• Format: Journal Article
• Language: English
• Published: United States American Psychiatric Association 01.09.2023
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Amygdala; Attention Deficit Disorder with Hyperactivity - genetics; Attention deficit hyperactivity disorder; Autism; Brain - diagnostic imaging; Child; DNA Copy Number Variations - genetics; Genomics; Humans; Male; Mental disorders; Middle Aged; Risk factors; Schizophrenia; Schizophrenia - genetics; Young Adult; Depressive Disorders; Neuroimaging; Genetics/Genomics; Neurodevelopmental Disorders; Schizophrenia Spectrum and Other Psychotic Disorders
• ISSN: 0002-953X; 1535-7228; 1535-7228
• DOI: 10.1176/appi.ajp.20220304

Copy number variants (CNVs) are well-known genetic pleiotropic risk factors for multiple neurodevelopmental and psychiatric disorders (NPDs), including autism (ASD) and schizophrenia. Little is known about how different CNVs conferring risk for the same condition may affect subcortical brain structu...