Effect of experimental uremia upon the estrous cycle in rats

By daily vaginal smears, uremic rats showed significantly greater prevalence of irregular estrous cycles compared with sham-operated controls (p less than 0.02). There seems to be a correlation between the degree of renal failure and estrous cycle abnormalities. The lack of LH surge on the afternoon...

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Bibliographic Details
Published inNephron (2015) Vol. 47; no. 1; p. 70
Main Authors da Costa e Silva, A, Campos, K N, Souza, P F, Albuquerque, R H, Martinelli, J G, Campos, G P, Ribeiro, R C
Format Journal Article
LanguageEnglish
Published Switzerland 1987
Subjects
Animals
Estrus
Female
Kidney Failure, Chronic - physiopathology
Luteinizing Hormone - blood
Nephrectomy
Rats
Urea - blood
Vaginal Smears
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Summary:By daily vaginal smears, uremic rats showed significantly greater prevalence of irregular estrous cycles compared with sham-operated controls (p less than 0.02). There seems to be a correlation between the degree of renal failure and estrous cycle abnormalities. The lack of LH surge on the afternoon of proestrus, found in uremic animals, suggests a defect in the positive hypothalamic steroid feedback.
ISSN:1660-8151
2235-3186
DOI:10.1159/000184460