A novel Schirmer strip-based tear matrix metalloproteinase measurement in dry eye evaluation

• Published in: The ocular surface Vol. 36; pp. 119 - 125
• Main Authors: Chen, Di, Li, Wubi, Yang, Shan, Song, Hang, Di, Yu, Zhong, Weixing, Zhang, Miao, Long, Qin, Li, Ying, Zhao, Chan
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2025
• Subjects: Adult; Aged; Biomarkers - metabolism; Chromatography, Affinity - methods; Diagnostic Techniques, Ophthalmological; Dry eye; Dry Eye Syndromes - diagnosis; Dry Eye Syndromes - enzymology; Dry Eye Syndromes - metabolism; Female; Fluorescence immunochromatography; Humans; Male; Matrix Metalloproteinase 9 - analysis; Matrix Metalloproteinase 9 - metabolism; Matrix metalloproteinase-9; Middle Aged; Reagent Strips; Reproducibility of Results; ROC Curve; Schirmer strip; Sensitivity and Specificity; Tear protein; Tears - enzymology; Young Adult; Matrix metalloproteinase-9; Tear protein; Dry eye; Fluorescence immunochromatography; Schirmer strip

The diagnosis and evaluation of dry eye require easy-to-use, precise, and consistent tools in clinical setting. Matrix metalloproteinase 9 (MMP-9) has been proven to be a reliable indicator of dry eye inflammation. The aim of this study is to establish an Eu-time resolved fluorescence immunochromato...