Specific increase in caspase-1 activity and secretion of IL-1 family cytokines: a putative link between mevalonate kinase deficiency and inflammation

• Published in: European cytokine network Vol. 20; no. 3; p. 101
• Main Authors: Normand, Sylvain, Massonnet, Benoit, Delwail, Adriana, Favot, Laure, Cuisset, Laurence, Grateau, Gilles, Morel, Franck, Silvain, Christine, Lecron, Jean-Claude
• Format: Journal Article
• Language: English
• Published: France 01.09.2009
• Subjects: Animals; Caspase 1 - metabolism; Disease Models, Animal; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; Inflammation - complications; Inflammation - enzymology; Inflammation - immunology; Interleukin-1 - secretion; Mevalonate Kinase Deficiency - complications; Mevalonate Kinase Deficiency - drug therapy; Mevalonate Kinase Deficiency - enzymology; Mevalonate Kinase Deficiency - immunology

The mevalonate kinase deficiency (MKD), including hyperimmunoglobulinemia D periodic fever syndrome (HIDS) and the more severe mevalonic aciduria are rare, autosomal recessive, autoinflammatory diseases belonging to the hereditary periodic fever (HPF) family. Other members include: familial mediterr...