Analysis of the env gene variability of the IDU-A HIV-1 variant in the outbreak of the HIV infection epidemic in Perm region of Russia (1996-2011)

• Published in: Voprosy virusologiĭ Vol. 61; no. 5; pp. 222 - 229
• Main Authors: Lebedev, Aleksey V, Kazennova, E V, Zverev, S Ya, Nistratova, Yu I, Laga, V Yu, Tumanov, A S, Glushchenko, N V, Yarygina, E I, Bobkova, M R
• Format: Journal Article
• Language: English
• Published: Russia (Federation) Central Research Institute for Epidemiology 2016
• Subjects: Adult; Codon; Disease Outbreaks; env Gene Products, Human Immunodeficiency Virus - genetics; evolution; Female; Gene Expression; Genetic Variation; group risk; Heterosexuality; HIV Infections - epidemiology; HIV Infections - transmission; HIV Infections - virology; hiv-1; HIV-1 - classification; HIV-1 - genetics; Humans; idu-a variant; Male; Mutation Rate; Phylogeny; Russia - epidemiology; Selection, Genetic; Substance Abuse, Intravenous - epidemiology; Substance Abuse, Intravenous - virology

In the present work, a total of 132 HIV-1 env gene C2-V3-C3 sequences belonging to the IDU-A genetic variant were analyzed. The variants were obtained from the viruses circulating among IDUs and heterosexuals in the Perm region at different periods. It was shown that the rate of the divergence of th...