Synthesis of the Cyclostellettamines A−F and Related Bis(3-alkylpyridinium) Macrocycles

• Published in: European journal of organic chemistry Vol. 1998; no. 5; pp. 889 - 895
• Main Authors: Wanner, Martin J., Koomen, Gerrit-Jan
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag GmbH 01.05.1998; WILEY‐VCH Verlag GmbH; Wiley
• Subjects: Chemistry; Chemistry, Organic; Macrocycles; Physical Sciences; Protecting groups; Science & Technology; Sponge alkaloids; protecting groups; sponge alkaloids; macrocycles; MARINE SPONGE; ALKALOIDS

A general method was developed for the synthesis of a variety of symmetric and asymmetric macrocyclic bispyridines. 3‐Hydroxyalkylpyridines 18−20 were prepared, converted to the corresponding iodides and protected on the pyridine nitrogen with a p‐methoxybenzyl group to give the crystalline precurso...