Development and Characterization of Pepducins as Gs-biased Allosteric Agonists - Carr, Richard; Du, Yang; Quoyer, Julie; Panettieri, Reynold A.; Janz, Jay M.; Bouvier, Michel; Kobilka, Brian K.; Benovic, Jeffrey L. (The Journal of biological chemistry, 2014)
Keywords: Adrenergic beta-Agonists - pharmacology; Adrenergic Receptor; Allosteric Regulation; Amino Acid Sequence; Asthma; Biased Agonist; Cyclic AMP - biosynthesis; Drug Discovery; Functional Selectivity; G Protein-coupled Receptor (GPCR); GTP-Binding Protein alpha Subunits, Gs - metabolism; HEK293 Cells; Humans; Molecular Sequence Data; Pepducin; Peptide Fragments - chemistry; Peptide Fragments - pharmacology; Peptide Library; Peptides; Phosphorylation; Protein Binding; Protein Processing, Post-Translational; Protein Structure, Tertiary; Protein Transport; Receptors, Adrenergic, beta-2 - chemistry; Receptors, Adrenergic, beta-2 - metabolism; Second Messenger Systems; Signal Transduction; β2-Adrenergic Receptor; Functional Selectivity; Peptides; Signal Transduction; Adrenergic Receptor; Pepducin; β2-Adrenergic Receptor; Biased Agonist; Drug Discovery; G Protein-coupled Receptor (GPCR); Asthma