Melatonin protects oocyte quality from Bisphenol A‐induced deterioration in the mouse
Bisphenol A (BPA) has been reported to adversely affect the mammalian reproductive system in both sexes. However, the underlying mechanisms regarding how BPA disrupts the mammalian oocyte quality and how to prevent it have not been fully defined. Here, we document that BPA weakens oocyte quality by...
Saved in:
Published in | Journal of pineal research Vol. 62; no. 3; pp. np - n/a |
---|---|
Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
01.04.2017
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Bisphenol A (BPA) has been reported to adversely affect the mammalian reproductive system in both sexes. However, the underlying mechanisms regarding how BPA disrupts the mammalian oocyte quality and how to prevent it have not been fully defined. Here, we document that BPA weakens oocyte quality by impairing both oocyte meiotic maturation and fertilization ability. We find that oral administration of BPA (100 μg/kg body weight per day for 7 days) compromises the first polar body extrusion (78.0% vs 57.0%, P<.05) by disrupting normal spindle assembly, chromosome alignment, and kinetochore‐microtubule attachment. This defect could be remarkably ameliorated (76.7%, P<.05) by concurrent oral administration of melatonin (30 mg/kg body weight per day for 7 days). In addition, BPA administration significantly decreases the fertilization rate of oocytes (87.2% vs 41.1%, P<.05) by reducing the number of sperm binding to the zona pellucida, which is consistent with the premature cleavage of ZP2 as well as the mis‐localization and decreased protein level of ovastacin. Also, the localization and protein level of Juno, the sperm receptor on the egg membrane, are strikingly impaired in BPA‐administered oocytes. Finally, we show that melatonin administration substantially elevates the in vitro fertilization rate (63.0%, P<.05) by restoring above defects of fertilization proteins and events, which might be mediated by the improvement of oocyte quality via reduction of ROS levels and inhibition of apoptosis. Collectively, our data reveal that melatonin has a protective action against BPA‐induced deterioration of oocyte quality in mice. |
---|---|
AbstractList | Abstract
Bisphenol A (BPA) has been reported to adversely affect the mammalian reproductive system in both sexes. However, the underlying mechanisms regarding how BPA disrupts the mammalian oocyte quality and how to prevent it have not been fully defined. Here, we document that BPA weakens oocyte quality by impairing both oocyte meiotic maturation and fertilization ability. We find that oral administration of BPA (100 μg/kg body weight per day for 7 days) compromises the first polar body extrusion (78.0% vs 57.0%,
P
<.05) by disrupting normal spindle assembly, chromosome alignment, and kinetochore‐microtubule attachment. This defect could be remarkably ameliorated (76.7%,
P
<.05) by concurrent oral administration of melatonin (30 mg/kg body weight per day for 7 days). In addition, BPA administration significantly decreases the fertilization rate of oocytes (87.2% vs 41.1%,
P
<.05) by reducing the number of sperm binding to the zona pellucida, which is consistent with the premature cleavage of ZP2 as well as the mis‐localization and decreased protein level of ovastacin. Also, the localization and protein level of Juno, the sperm receptor on the egg membrane, are strikingly impaired in BPA‐administered oocytes. Finally, we show that melatonin administration substantially elevates the in vitro fertilization rate (63.0%,
P
<.05) by restoring above defects of fertilization proteins and events, which might be mediated by the improvement of oocyte quality via reduction of ROS levels and inhibition of apoptosis. Collectively, our data reveal that melatonin has a protective action against BPA‐induced deterioration of oocyte quality in mice. Bisphenol A (BPA) has been reported to adversely affect the mammalian reproductive system in both sexes. However, the underlying mechanisms regarding how BPA disrupts the mammalian oocyte quality and how to prevent it have not been fully defined. Here, we document that BPA weakens oocyte quality by impairing both oocyte meiotic maturation and fertilization ability. We find that oral administration of BPA (100 μg/kg body weight per day for 7 days) compromises the first polar body extrusion (78.0% vs 57.0%, P<.05) by disrupting normal spindle assembly, chromosome alignment, and kinetochore‐microtubule attachment. This defect could be remarkably ameliorated (76.7%, P<.05) by concurrent oral administration of melatonin (30 mg/kg body weight per day for 7 days). In addition, BPA administration significantly decreases the fertilization rate of oocytes (87.2% vs 41.1%, P<.05) by reducing the number of sperm binding to the zona pellucida, which is consistent with the premature cleavage of ZP2 as well as the mis‐localization and decreased protein level of ovastacin. Also, the localization and protein level of Juno, the sperm receptor on the egg membrane, are strikingly impaired in BPA‐administered oocytes. Finally, we show that melatonin administration substantially elevates the in vitro fertilization rate (63.0%, P<.05) by restoring above defects of fertilization proteins and events, which might be mediated by the improvement of oocyte quality via reduction of ROS levels and inhibition of apoptosis. Collectively, our data reveal that melatonin has a protective action against BPA‐induced deterioration of oocyte quality in mice. Bisphenol A (BPA) has been reported to adversely affect the mammalian reproductive system in both sexes. However, the underlying mechanisms regarding how BPA disrupts the mammalian oocyte quality and how to prevent it have not been fully defined. Here, we document that BPA weakens oocyte quality by impairing both oocyte meiotic maturation and fertilization ability. We find that oral administration of BPA (100 μg/kg body weight per day for 7 days) compromises the first polar body extrusion (78.0% vs 57.0%, P<.05) by disrupting normal spindle assembly, chromosome alignment, and kinetochore-microtubule attachment. This defect could be remarkably ameliorated (76.7%, P<.05) by concurrent oral administration of melatonin (30 mg/kg body weight per day for 7 days). In addition, BPA administration significantly decreases the fertilization rate of oocytes (87.2% vs 41.1%, P<.05) by reducing the number of sperm binding to the zona pellucida, which is consistent with the premature cleavage of ZP2 as well as the mis-localization and decreased protein level of ovastacin. Also, the localization and protein level of Juno, the sperm receptor on the egg membrane, are strikingly impaired in BPA-administered oocytes. Finally, we show that melatonin administration substantially elevates the in vitro fertilization rate (63.0%, P<.05) by restoring above defects of fertilization proteins and events, which might be mediated by the improvement of oocyte quality via reduction of ROS levels and inhibition of apoptosis. Collectively, our data reveal that melatonin has a protective action against BPA-induced deterioration of oocyte quality in mice. Bisphenol A (BPA) has been reported to adversely affect the mammalian reproductive system in both sexes. However, the underlying mechanisms regarding how BPA disrupts the mammalian oocyte quality and how to prevent it have not been fully defined. Here, we document that BPA weakens oocyte quality by impairing both oocyte meiotic maturation and fertilization ability. We find that oral administration of BPA (100 mu g/kg body weight per day for 7 days) compromises the first polar body extrusion (78.0% vs 57.0%, P<.05) by disrupting normal spindle assembly, chromosome alignment, and kinetochore-microtubule attachment. This defect could be remarkably ameliorated (76.7%, P<.05) by concurrent oral administration of melatonin (30 mg/kg body weight per day for 7 days). In addition, BPA administration significantly decreases the fertilization rate of oocytes (87.2% vs 41.1%, P<.05) by reducing the number of sperm binding to the zona pellucida, which is consistent with the premature cleavage of ZP2 as well as the mis-localization and decreased protein level of ovastacin. Also, the localization and protein level of Juno, the sperm receptor on the egg membrane, are strikingly impaired in BPA-administered oocytes. Finally, we show that melatonin administration substantially elevates the in vitro fertilization rate (63.0%, P<.05) by restoring above defects of fertilization proteins and events, which might be mediated by the improvement of oocyte quality via reduction of ROS levels and inhibition of apoptosis. Collectively, our data reveal that melatonin has a protective action against BPA-induced deterioration of oocyte quality in mice. |
Author | Dai, Xiaoxin Xiong, Bo Zhang, Mianqun Zhou, Changyin Liu, Honglin Lu, Yajuan Miao, Yilong Cui, Zhaokang |
Author_xml | – sequence: 1 givenname: Mianqun surname: Zhang fullname: Zhang, Mianqun organization: Nanjing Agricultural University – sequence: 2 givenname: Xiaoxin surname: Dai fullname: Dai, Xiaoxin organization: Nanjing Agricultural University – sequence: 3 givenname: Yajuan surname: Lu fullname: Lu, Yajuan organization: Nanjing Agricultural University – sequence: 4 givenname: Yilong surname: Miao fullname: Miao, Yilong organization: Nanjing Agricultural University – sequence: 5 givenname: Changyin surname: Zhou fullname: Zhou, Changyin organization: Nanjing Agricultural University – sequence: 6 givenname: Zhaokang surname: Cui fullname: Cui, Zhaokang organization: Nanjing Agricultural University – sequence: 7 givenname: Honglin surname: Liu fullname: Liu, Honglin organization: Nanjing Agricultural University – sequence: 8 givenname: Bo orcidid: 0000-0003-2456-4559 surname: Xiong fullname: Xiong, Bo email: xiongbo@njau.edu.cn organization: Nanjing Agricultural University |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28178360$$D View this record in MEDLINE/PubMed |
BookMark | eNqNkLtOwzAUQC0EgrYw8APIIwxp7TjxY4SKRxEIBhBskRvfCKMkLrEj1I1P4Bv5EgwtbEjc5S5HR_eeIdpsXQsI7VMypnEmzws7pilTfAMNKCckIUI9bqIBEVmaMKLkDhp6_0wIkVLybbSTSiok42SAHq6h1sG1tsWLzgUog8fOlcsA-KXXtQ1LXHWuwSfWL56gdTU-_nh7t63pSzDYQIDOuk4H61ocHeEJcON6D7toq9K1h731HqH7s9O76UVydXM-mx5fJSXLJU-4lsbokpE0l6VQqZFaQqVYWlEwDICpPJNCMU2EyUWu5tmcGUVZRpTOQGg2Qocrb7z-pQcfisb6EupatxDvKGj8WAlFUvkPlHOu0kyyiB6t0LJz3ndQFYvONrpbFpQUX8mLmLz4Th7Zg7W2nzdgfsmfxhGYrIBXW8Pyb1NxeTtbKT8Btc6Nzw |
CitedBy_id | crossref_primary_10_1016_j_envres_2019_108575 crossref_primary_10_1016_j_theriogenology_2021_07_025 crossref_primary_10_1038_s41419_022_04948_w crossref_primary_10_1016_j_ecoenv_2024_116559 crossref_primary_10_1016_j_reprotox_2020_01_004 crossref_primary_10_1111_jpi_12577 crossref_primary_10_1096_fj_201700514r crossref_primary_10_3390_ijms20163921 crossref_primary_10_18311_ti_2021_v28i4_27473 crossref_primary_10_1111_jpi_12497 crossref_primary_10_1111_jpi_12530 crossref_primary_10_3390_antiox9050405 crossref_primary_10_1093_abbs_gmab108 crossref_primary_10_1111_jpi_12532 crossref_primary_10_1007_s11356_024_33148_6 crossref_primary_10_1002_jcp_28018 crossref_primary_10_1016_j_talanta_2024_126472 crossref_primary_10_1016_j_anireprosci_2018_02_018 crossref_primary_10_1016_j_chemosphere_2020_126819 crossref_primary_10_1002_mnfr_202300401 crossref_primary_10_1007_s43032_020_00359_4 crossref_primary_10_1080_10520295_2019_1627418 crossref_primary_10_1002_tox_23494 crossref_primary_10_1096_fj_201700908R crossref_primary_10_1111_cpr_13419 crossref_primary_10_1111_jpi_12601 crossref_primary_10_18632_aging_102703 crossref_primary_10_1111_rda_14262 crossref_primary_10_1016_j_ecoenv_2021_112783 crossref_primary_10_1111_rda_13890 crossref_primary_10_1016_j_redox_2021_102215 crossref_primary_10_1155_2020_5183017 crossref_primary_10_1186_s40360_019_0323_9 crossref_primary_10_18632_aging_202323 crossref_primary_10_1080_15569543_2024_2304770 crossref_primary_10_1016_j_envpol_2021_118445 crossref_primary_10_1093_biolre_ioac043 crossref_primary_10_1016_j_chemosphere_2020_126762 crossref_primary_10_1080_15384101_2017_1380133 crossref_primary_10_1002_jcp_27351 crossref_primary_10_1002_em_22258 crossref_primary_10_1111_jpi_12718 crossref_primary_10_1016_j_theriogenology_2019_12_011 crossref_primary_10_1002_tox_22851 crossref_primary_10_1016_j_envpol_2023_121482 crossref_primary_10_1530_REP_18_0092 crossref_primary_10_1002_ctm2_1236 crossref_primary_10_18632_aging_101405 crossref_primary_10_25259_JRHM_39_2020 crossref_primary_10_1111_jpi_12431 crossref_primary_10_1111_jpi_12477 crossref_primary_10_1016_j_ecoenv_2021_113105 crossref_primary_10_1002_jcp_28357 crossref_primary_10_1016_j_brainresbull_2021_06_010 crossref_primary_10_3390_ijms19113422 crossref_primary_10_1093_biolre_ioae077 crossref_primary_10_3389_fcell_2021_661155 crossref_primary_10_3389_fphar_2021_708645 crossref_primary_10_1007_s11626_019_00373_0 crossref_primary_10_1016_j_ecoenv_2024_116703 crossref_primary_10_1111_jpi_12627 crossref_primary_10_1111_jpi_12869 crossref_primary_10_1016_j_chemosphere_2020_126110 crossref_primary_10_1186_s12958_022_00938_x crossref_primary_10_2903_j_efsa_2023_6857 crossref_primary_10_18632_aging_101715 crossref_primary_10_1016_j_bbamcr_2023_119505 crossref_primary_10_1016_j_jhazmat_2023_132997 crossref_primary_10_1016_j_ygcen_2021_113962 crossref_primary_10_3389_fcell_2021_693969 crossref_primary_10_18632_aging_203231 |
Cites_doi | 10.1111/j.1600-079X.2008.00602.x 10.1016/j.cub.2015.12.034 10.1530/REP-11-0118 10.1016/S0960-9822(03)00189-1 10.1093/molehr/5.5.402 10.1177/074823379801400115 10.1186/s13048-014-0098-y 10.1080/21541264.2015.1127315 10.14219/jada.archive.2000.0019 10.1016/j.freeradbiomed.2012.01.030 10.1111/j.1439-0531.2007.00982.x 10.1016/j.reprotox.2007.06.007 10.1111/j.1600-079X.2008.00614.x 10.1016/S0014-2999(01)01511-4 10.1385/ENDO:27:2:119 10.1073/pnas.1214056110 10.1155/2015/854359 10.1016/j.pedn.2009.05.006 10.2741/4075 10.1038/nature18595 10.4103/0976-0105.177703 10.1038/ncb3065 10.1111/jpi.12162 10.1111/j.1600-079X.2011.00916.x 10.1056/NEJM199804023381411 10.1016/S0027-5107(99)00190-6 10.1038/nature18596 10.1016/0012-1606(81)90329-8 10.1016/0014-5793(92)80502-8 10.1016/j.tox.2006.09.018 10.1083/jcb.201506020 10.1111/j.1600-079X.2012.01014.x 10.1038/nature13203 10.2174/187152907781745297 10.1016/S0015-0282(03)01008-2 10.1289/ehp.02110s3403 10.1016/j.jns.2014.10.009 10.1016/j.tox.2008.10.022 10.2174/1568026023394443 10.1289/ehp.0901717 10.1016/j.intimp.2015.10.012 10.1016/S0165-1218(96)00161-9 10.1016/j.taap.2015.02.006 10.4161/cc.28046 10.1002/(SICI)1097-0215(19980119)75:2<290::AID-IJC19>3.0.CO;2-H 10.18388/abp.2003_3637 10.1111/j.1600-079X.2007.00524.x 10.1016/j.fct.2010.07.019 10.1210/endo.132.6.8504731 10.1111/j.1600-079X.2006.00407.x 10.1111/j.1600-079X.2005.00282.x 10.1002/(SICI)1097-0215(20000415)86:2<151::AID-IJC1>3.0.CO;2-0 10.1289/ehp.95103608 10.1111/jpi.12070 10.1016/j.reprotox.2006.09.005 10.1016/j.ejphar.2014.12.002 10.1034/j.1600-079X.2000.290303.x 10.1111/jpi.12360 10.1093/molehr/gat004 10.1083/jcb.201112094 |
ContentType | Journal Article |
Copyright | 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
Copyright_xml | – notice: 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd – notice: 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 7TK |
DOI | 10.1111/jpi.12396 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic Neurosciences Abstracts |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic Neurosciences Abstracts |
DatabaseTitleList | CrossRef MEDLINE - Academic Neurosciences Abstracts MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Anatomy & Physiology |
EISSN | 1600-079X |
EndPage | n/a |
ExternalDocumentID | 10_1111_jpi_12396 28178360 JPI12396 |
Genre | article Journal Article |
GrantInformation_xml | – fundername: Natural Science Foundation of Jiangsu Province funderid: BK20150677 – fundername: National Natural Science Foundation of China funderid: 31571545 |
GroupedDBID | --- .3N .GA .GJ .Y3 05W 0R~ 10A 186 1OB 1OC 29L 31~ 33P 36B 3O- 3SF 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5HH 5LA 5RE 5VS 66C 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAESR AAEVG AAHHS AAKAS AANLZ AAONW AASGY AAXRX AAZKR ABCQN ABCUV ABDBF ABEML ABPVW ABQWH ABXGK ACAHQ ACBWZ ACCFJ ACCZN ACGFO ACGFS ACGOF ACMXC ACPOU ACSCC ACXBN ACXQS ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADOZA ADXAS ADZCM ADZMN AEEZP AEGXH AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFEBI AFFPM AFGKR AFPWT AFZJQ AHBTC AHEFC AIACR AIAGR AITYG AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMXJE BQCPF BROTX BRXPI BY8 C45 CAG COF CS3 D-6 D-7 D-E D-F DC6 DCZOG DPXWK DR2 DRFUL DRMAN DRSTM DU5 EAD EAP EBC EBD EBS EBX EJD EMB EMK EMOBN ESX EX3 F00 F01 F04 F5P FEDTE FUBAC FZ0 G-S G.N GODZA H.X HF~ HGLYW HVGLF HZI HZ~ IHE IX1 J0M K48 KBYEO LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ O66 O9- OIG OVD P2P P2W P2X P2Z P4B P4D PALCI Q.N Q11 QB0 R.K RIWAO RJQFR ROL RX1 SAMSI SUPJJ SV3 TEORI TUS UB1 V8K W8V W99 WBKPD WIH WIJ WIK WNSPC WOHZO WOW WQJ WRC WXI WXSBR WYISQ XG1 YFH YUY ZZTAW ~IA ~WT CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 7TK |
ID | FETCH-LOGICAL-c3586-6a8ddac30258c792d8a8ef932f1ed3ee39548793a07d5759b4b3d913409a4e7a3 |
IEDL.DBID | DR2 |
ISSN | 0742-3098 |
IngestDate | Sat Aug 17 01:21:20 EDT 2024 Fri Aug 16 23:51:26 EDT 2024 Fri Aug 23 02:19:40 EDT 2024 Sat Sep 28 08:09:00 EDT 2024 Sat Aug 24 00:46:54 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 3 |
Keywords | Bisphenol A ovastacin fertilization spindle assembly oocyte maturation melatonin Juno |
Language | English |
License | 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c3586-6a8ddac30258c792d8a8ef932f1ed3ee39548793a07d5759b4b3d913409a4e7a3 |
Notes | Funding information This work was supported by the National Natural Science Foundation of China (31571545) and the Natural Science Foundation of Jiangsu Province (BK20150677) ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ORCID | 0000-0003-2456-4559 |
PMID | 28178360 |
PQID | 1866692483 |
PQPubID | 23479 |
PageCount | 13 |
ParticipantIDs | proquest_miscellaneous_1888979028 proquest_miscellaneous_1866692483 crossref_primary_10_1111_jpi_12396 pubmed_primary_28178360 wiley_primary_10_1111_jpi_12396_JPI12396 |
PublicationCentury | 2000 |
PublicationDate | April 2017 2017-Apr 2017-04-00 20170401 |
PublicationDateYYYYMMDD | 2017-04-01 |
PublicationDate_xml | – month: 04 year: 2017 text: April 2017 |
PublicationDecade | 2010 |
PublicationPlace | England |
PublicationPlace_xml | – name: England |
PublicationTitle | Journal of pineal research |
PublicationTitleAlternate | J Pineal Res |
PublicationYear | 2017 |
References | 2009; 44 2009; 46 2002; 110 2000; 86 2003; 13 2000; 131 2015; 747 2012; 17 2005; 27 2003; 50 1993; 1 1981; 86 2012; 52 2013; 19 2010; 25 2010; 118 2013; 55 2013; 54 2015; 210 2014; 16 2014; 57 2007; 7 2014; 13 2013; 110 1997; 390 2014; 7 2007; 23 1993; 132 2007; 24 1998; 14 2015; 284 2009; 25 2000; 29 2003; 80 1992; 303 1998; 338 2002; 2 2009; 256 1999; 5 2001; 432 2014; 347 2016; 7 2012; 197 2010; 48 2014; 508 2015; 29 2006; 40 2011; 51 2015; 2015 2016; 61 1995; 103 2008; 44 2016; 534 1999; 431 2007; 42 2006; 228 1998; 75 2016; 26 2011; 142 e_1_2_7_5_1 e_1_2_7_3_1 e_1_2_7_9_1 e_1_2_7_7_1 e_1_2_7_60_1 e_1_2_7_17_1 e_1_2_7_62_1 e_1_2_7_15_1 e_1_2_7_41_1 e_1_2_7_13_1 e_1_2_7_43_1 e_1_2_7_11_1 e_1_2_7_45_1 Tan DX (e_1_2_7_36_1) 1993; 1 e_1_2_7_47_1 e_1_2_7_26_1 e_1_2_7_49_1 e_1_2_7_28_1 e_1_2_7_50_1 e_1_2_7_25_1 e_1_2_7_31_1 e_1_2_7_52_1 e_1_2_7_23_1 e_1_2_7_33_1 e_1_2_7_54_1 e_1_2_7_21_1 e_1_2_7_35_1 e_1_2_7_56_1 e_1_2_7_37_1 e_1_2_7_58_1 e_1_2_7_39_1 e_1_2_7_6_1 e_1_2_7_4_1 e_1_2_7_8_1 e_1_2_7_18_1 e_1_2_7_16_1 e_1_2_7_40_1 e_1_2_7_61_1 e_1_2_7_2_1 e_1_2_7_14_1 e_1_2_7_42_1 e_1_2_7_63_1 e_1_2_7_12_1 e_1_2_7_44_1 e_1_2_7_10_1 e_1_2_7_46_1 e_1_2_7_48_1 e_1_2_7_27_1 e_1_2_7_29_1 Huang MD (e_1_2_7_19_1) 2009; 25 e_1_2_7_51_1 e_1_2_7_30_1 e_1_2_7_53_1 e_1_2_7_24_1 e_1_2_7_32_1 e_1_2_7_55_1 e_1_2_7_22_1 e_1_2_7_34_1 e_1_2_7_57_1 e_1_2_7_20_1 e_1_2_7_59_1 e_1_2_7_38_1 |
References_xml | – volume: 80 start-page: 1012 year: 2003 end-page: 1016 article-title: Increased endogenous level of melatonin in preovulatory human follicles does not directly influence progesterone production publication-title: Fertil Steril – volume: 7 start-page: 27 year: 2016 end-page: 31 article-title: A simple practice guide for dose conversion between animals and human publication-title: J Basic Clin Pharm – volume: 110 start-page: 403 issue: Suppl 3 year: 2002 end-page: 407 article-title: Effects of perinatal exposure to bisphenol A on play behavior of female and male juvenile rats publication-title: Environ Health Perspect – volume: 256 start-page: 7 year: 2009 end-page: 12 article-title: Iron deficiency augments bisphenol A‐induced oxidative stress in rats publication-title: Toxicology – volume: 25 start-page: 539 year: 2009 end-page: 542 article-title: The protective effect of melatonin on auditory cortex toxicity induced by cis‐platinum publication-title: Zhongguo Ying Yong Sheng Li Xue Za Zhi – volume: 42 start-page: 28 year: 2007 end-page: 42 article-title: One molecule, many derivatives: a never‐ending interaction of melatonin with reactive oxygen and nitrogen species? publication-title: J Pineal Res – volume: 54 start-page: 1 year: 2013 end-page: 14 article-title: A review of the molecular aspects of melatonin's anti‐inflammatory actions: recent insights and new perspectives publication-title: J Pineal Res – volume: 17 start-page: 2644 year: 2012 end-page: 2656 article-title: The role of melatonin treatment in chronic kidney disease publication-title: Front Biosci (Landmark Ed) – volume: 1 start-page: 57 year: 1993 end-page: 60 article-title: Melatonin: a potent, endogenous hydroxyl radical scavenger publication-title: Endocr J – volume: 14 start-page: 239 year: 1998 end-page: 260 article-title: A physiologically based approach to the study of bisphenol A and other estrogenic chemicals on the size of reproductive organs, daily sperm production, and behavior publication-title: Toxicol Ind Health – volume: 51 start-page: 1 year: 2011 end-page: 16 article-title: Melatonin as a natural ally against oxidative stress: a physicochemical examination publication-title: J Pineal Res – volume: 197 start-page: 37 year: 2012 end-page: 44 article-title: Ovastacin, a cortical granule protease, cleaves ZP2 in the zona pellucida to prevent polyspermy publication-title: J Cell Biol – volume: 13 start-page: 546 year: 2003 end-page: 553 article-title: Bisphenol A exposure causes meiotic aneuploidy in the female mouse publication-title: Curr Biol – volume: 50 start-page: 1129 year: 2003 end-page: 1146 article-title: Melatonin as an antioxidant: biochemical mechanisms and pathophysiological implications in humans publication-title: Acta Biochim Pol – volume: 103 start-page: 608 year: 1995 end-page: 612 article-title: Xenoestrogens released from lacquer coatings in food cans publication-title: Environ Health Perspect – volume: 7 start-page: 21 year: 2016 end-page: 25 article-title: Insights into centromeric transcription in mitosis publication-title: Transcription – volume: 26 start-page: R100 year: 2016 end-page: R101 article-title: Divergent evolution of vitamin B9 binding underlies Juno‐mediated adhesion of mammalian gametes publication-title: Curr Biol – volume: 5 start-page: 402 year: 1999 end-page: 408 article-title: Melatonin, its precursors, and synthesizing enzyme activities in the human ovary publication-title: Mol Hum Reprod – volume: 534 start-page: 566 year: 2016 end-page: 569 article-title: Structure of IZUMO1‐JUNO reveals sperm‐oocyte recognition during mammalian fertilization publication-title: Nature – volume: 347 start-page: 251 year: 2014 end-page: 256 article-title: Melatonin ameliorates oxidative stress, modulates death receptor pathway proteins, and protects the rat cerebrum against bisphenol‐A‐induced apoptosis publication-title: J Neurol Sci – volume: 61 start-page: 253 year: 2016 end-page: 278 article-title: Melatonin as an antioxidant: under promises but over delivers publication-title: J Pineal Res – volume: 118 start-page: 1051 year: 2010 end-page: 1054 article-title: Biomonitoring studies should be used by regulatory agencies to assess human exposure levels and safety of bisphenol A publication-title: Environ Health Perspect – volume: 24 start-page: 259 year: 2007 end-page: 264 article-title: Bisphenol‐A and chlorinated derivatives in adipose tissue of women publication-title: Reprod Toxicol – volume: 52 start-page: 1634 year: 2012 end-page: 1647 article-title: Melatonin ameliorates neural function by promoting endogenous neurogenesis through the MT2 melatonin receptor in ischemic‐stroke mice publication-title: Free Radic Biol Med – volume: 25 start-page: 400 year: 2010 end-page: 407 article-title: Bisphenol a exposure: human risk and health policy publication-title: J Pediatr Nurs – volume: 27 start-page: 119 year: 2005 end-page: 130 article-title: Antioxidative protection by melatonin: multiplicity of mechanisms from radical detoxification to radical avoidance publication-title: Endocrine – volume: 7 start-page: 98 year: 2014 article-title: Melatonin: shedding light on infertility? A review of the recent literature publication-title: J Ovarian Res – volume: 48 start-page: 2865 year: 2010 end-page: 2871 article-title: Influence of vitamin C on bisphenol A, nonylphenol and octylphenol induced oxidative damages in liver of male rats publication-title: Food Chem Toxicol – volume: 2015 start-page: 854359 year: 2015 article-title: The protective effect of melatonin on neural stem cell against LPS‐induced inflammation publication-title: Biomed Res Int – volume: 40 start-page: 1 year: 2006 end-page: 9 article-title: Melatonin as a cytoskeletal modulator: implications for cell physiology and disease publication-title: J Pineal Res – volume: 57 start-page: 131 year: 2014 end-page: 146 article-title: Melatonin: a well‐documented antioxidant with conditional pro‐oxidant actions publication-title: J Pineal Res – volume: 747 start-page: 166 year: 2015 end-page: 173 article-title: Melatonin ameliorates metabolic risk factors, modulates apoptotic proteins, and protects the rat heart against diabetes‐induced apoptosis publication-title: Eur J Pharmacol – volume: 86 start-page: 189 year: 1981 end-page: 197 article-title: Mammalian sperm‐egg interaction: fertilization of mouse eggs triggers modification of the major zona pellucida glycoprotein, ZP2 publication-title: Dev Biol – volume: 55 start-page: 275 year: 2013 end-page: 286 article-title: JAK2/STAT3 activation by melatonin attenuates the mitochondrial oxidative damage induced by myocardial ischemia/reperfusion injury publication-title: J Pineal Res – volume: 2 start-page: 181 year: 2002 end-page: 197 article-title: Chemical and physical properties and potential mechanisms: melatonin as a broad spectrum antioxidant and free radical scavenger publication-title: Curr Top Med Chem – volume: 431 start-page: 105 year: 1999 end-page: 121 article-title: Induction of multiple microtubule‐organizing centers, multipolar spindles and multipolar division in cultured V79 cells exposed to diethylstilbestrol, estradiol‐17beta and bisphenol A publication-title: Mutat Res – volume: 16 start-page: 1257 year: 2014 end-page: 1264 article-title: Negative feedback at kinetochores underlies a responsive spindle checkpoint signal publication-title: Nat Cell Biol – volume: 7 start-page: 163 year: 2007 end-page: 169 article-title: Melatonin in cardiac ischemia/reperfusion‐induced mitochondrial adaptive changes publication-title: Cardiovasc Hematol Disord Drug Targets – volume: 390 start-page: 21 year: 1997 end-page: 31 article-title: Interference with microtubules and induction of micronuclei in vitro by various bisphenols publication-title: Mutat Res – volume: 432 start-page: 163 year: 2001 end-page: 166 article-title: Involvement of benzodiazepine binding sites in an antiaggressive effect by 5‐HT(1A) receptor activation in isolated mice publication-title: Eur J Pharmacol – volume: 284 start-page: 227 year: 2015 end-page: 235 article-title: A novel synthetic derivative of melatonin, 5‐hydroxy‐2′‐isobutyl‐streptochlorin (HIS), inhibits inflammatory responses via regulation of TRIF‐dependent signaling and inflammasome activation publication-title: Toxicol Appl Pharmacol – volume: 110 start-page: 9956 year: 2013 end-page: 9961 article-title: Sex‐specific epigenetic disruption and behavioral changes following low‐dose in utero bisphenol A exposure publication-title: Proc Natl Acad Sci USA – volume: 29 start-page: 462 year: 2015 end-page: 467 article-title: Melatonin prevents lung injury induced by hepatic ischemia‐reperfusion through anti‐inflammatory and anti‐apoptosis effects publication-title: Int Immunopharmacol – volume: 508 start-page: 483 year: 2014 end-page: 487 article-title: Juno is the egg Izumo receptor and is essential for mammalian fertilization publication-title: Nature – volume: 132 start-page: 2279 year: 1993 end-page: 2286 article-title: Bisphenol‐A: an estrogenic substance is released from polycarbonate flasks during autoclaving publication-title: Endocrinology – volume: 228 start-page: 333 year: 2006 end-page: 343 article-title: Melatonin has dose‐dependent effects on folliculogenesis, oocyte maturation capacity and steroidogenesis publication-title: Toxicology – volume: 46 start-page: 49 year: 2009 end-page: 52 article-title: The melatonin metabolite N‐acetyl‐5‐methoxykynuramine is a potent singlet oxygen scavenger publication-title: J Pineal Res – volume: 303 start-page: 121 year: 1992 end-page: 125 article-title: Dynamic aspects of ovarian superoxide dismutase isozymes during the ovulatory process in the rat publication-title: FEBS Lett – volume: 142 start-page: 377 year: 2011 end-page: 381 article-title: The molecular basis of mouse sperm‐zona pellucida binding: a still unresolved issue in developmental biology publication-title: Reproduction – volume: 13 start-page: 1171 year: 2014 end-page: 1179 article-title: Kinetochore microtubule establishment is defective in oocytes from aged mice publication-title: Cell Cycle – volume: 75 start-page: 290 year: 1998 end-page: 294 article-title: Bisphenol‐A induces cellular transformation, aneuploidy and DNA adduct formation in cultured Syrian hamster embryo cells publication-title: Int J Cancer – volume: 44 start-page: 280 year: 2008 end-page: 287 article-title: Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate publication-title: J Pineal Res – volume: 210 start-page: 899 year: 2015 end-page: 916 article-title: Kinetochore function is controlled by a phospho‐dependent coexpansion of inner and outer components publication-title: J Cell Biol – volume: 19 start-page: 279 year: 2013 end-page: 289 article-title: The molecular basis of gamete recognition in mice and humans publication-title: Mol Hum Reprod – volume: 23 start-page: 138 year: 2007 end-page: 144 article-title: Influence of oral and subcutaneous bisphenol‐A on intrauterine implantation of fertilized ova in inseminated female mice publication-title: Reprod Toxicol – volume: 534 start-page: 562 year: 2016 end-page: 565 article-title: Molecular architecture of the human sperm IZUMO1 and egg JUNO fertilization complex publication-title: Nature – volume: 29 start-page: 143 year: 2000 end-page: 151 article-title: Melatonin protects against stress‐induced gastric lesions by scavenging the hydroxyl radical publication-title: J Pineal Res – volume: 46 start-page: 22 year: 2009 end-page: 28 article-title: Effects of melatonin on in vitro maturation of porcine oocyte and expression of melatonin receptor RNA in cumulus and granulosa cells publication-title: J Pineal Res – volume: 338 start-page: 988 year: 1998 end-page: 991 article-title: Organochlorine residues and breast cancer publication-title: N Engl J Med – volume: 131 start-page: 51 year: 2000 end-page: 58 article-title: Pharmacokinetics of bisphenol A released from a dental sealant publication-title: J Am Dent Assoc – volume: 86 start-page: 151 year: 2000 end-page: 154 article-title: Mammalian cell transformation and aneuploidy induced by five bisphenols publication-title: Int J Cancer – volume: 44 start-page: 12 year: 2009 end-page: 16 article-title: Effect of taurine and melatonin in the culture medium on buffalo in vitro embryo development publication-title: Reprod Domest Anim – ident: e_1_2_7_40_1 doi: 10.1111/j.1600-079X.2008.00602.x – ident: e_1_2_7_61_1 doi: 10.1016/j.cub.2015.12.034 – ident: e_1_2_7_58_1 doi: 10.1530/REP-11-0118 – ident: e_1_2_7_46_1 doi: 10.1016/S0960-9822(03)00189-1 – ident: e_1_2_7_42_1 doi: 10.1093/molehr/5.5.402 – ident: e_1_2_7_48_1 doi: 10.1177/074823379801400115 – ident: e_1_2_7_62_1 doi: 10.1186/s13048-014-0098-y – ident: e_1_2_7_52_1 doi: 10.1080/21541264.2015.1127315 – ident: e_1_2_7_3_1 doi: 10.14219/jada.archive.2000.0019 – ident: e_1_2_7_17_1 doi: 10.1016/j.freeradbiomed.2012.01.030 – ident: e_1_2_7_39_1 doi: 10.1111/j.1439-0531.2007.00982.x – ident: e_1_2_7_11_1 doi: 10.1016/j.reprotox.2007.06.007 – ident: e_1_2_7_35_1 doi: 10.1111/j.1600-079X.2008.00614.x – ident: e_1_2_7_16_1 doi: 10.1016/S0014-2999(01)01511-4 – ident: e_1_2_7_33_1 doi: 10.1385/ENDO:27:2:119 – ident: e_1_2_7_47_1 doi: 10.1073/pnas.1214056110 – ident: e_1_2_7_26_1 doi: 10.1155/2015/854359 – ident: e_1_2_7_14_1 doi: 10.1016/j.pedn.2009.05.006 – ident: e_1_2_7_28_1 doi: 10.2741/4075 – ident: e_1_2_7_54_1 doi: 10.1038/nature18595 – ident: e_1_2_7_63_1 doi: 10.4103/0976-0105.177703 – ident: e_1_2_7_51_1 doi: 10.1038/ncb3065 – ident: e_1_2_7_21_1 doi: 10.1111/jpi.12162 – ident: e_1_2_7_23_1 doi: 10.1111/j.1600-079X.2011.00916.x – ident: e_1_2_7_15_1 doi: 10.1056/NEJM199804023381411 – volume: 1 start-page: 57 year: 1993 ident: e_1_2_7_36_1 article-title: Melatonin: a potent, endogenous hydroxyl radical scavenger publication-title: Endocr J contributor: fullname: Tan DX – ident: e_1_2_7_8_1 doi: 10.1016/S0027-5107(99)00190-6 – ident: e_1_2_7_55_1 doi: 10.1038/nature18596 – ident: e_1_2_7_56_1 doi: 10.1016/0012-1606(81)90329-8 – ident: e_1_2_7_45_1 doi: 10.1016/0014-5793(92)80502-8 – ident: e_1_2_7_38_1 doi: 10.1016/j.tox.2006.09.018 – ident: e_1_2_7_50_1 doi: 10.1083/jcb.201506020 – ident: e_1_2_7_27_1 doi: 10.1111/j.1600-079X.2012.01014.x – ident: e_1_2_7_60_1 doi: 10.1038/nature13203 – ident: e_1_2_7_24_1 doi: 10.2174/187152907781745297 – ident: e_1_2_7_43_1 doi: 10.1016/S0015-0282(03)01008-2 – ident: e_1_2_7_49_1 doi: 10.1289/ehp.02110s3403 – ident: e_1_2_7_30_1 doi: 10.1016/j.jns.2014.10.009 – ident: e_1_2_7_6_1 doi: 10.1016/j.tox.2008.10.022 – ident: e_1_2_7_37_1 doi: 10.2174/1568026023394443 – ident: e_1_2_7_10_1 doi: 10.1289/ehp.0901717 – ident: e_1_2_7_31_1 doi: 10.1016/j.intimp.2015.10.012 – ident: e_1_2_7_9_1 doi: 10.1016/S0165-1218(96)00161-9 – ident: e_1_2_7_25_1 doi: 10.1016/j.taap.2015.02.006 – ident: e_1_2_7_53_1 doi: 10.4161/cc.28046 – ident: e_1_2_7_7_1 doi: 10.1002/(SICI)1097-0215(19980119)75:2<290::AID-IJC19>3.0.CO;2-H – ident: e_1_2_7_34_1 doi: 10.18388/abp.2003_3637 – ident: e_1_2_7_44_1 doi: 10.1111/j.1600-079X.2007.00524.x – ident: e_1_2_7_12_1 doi: 10.1016/j.fct.2010.07.019 – ident: e_1_2_7_4_1 doi: 10.1210/endo.132.6.8504731 – ident: e_1_2_7_20_1 doi: 10.1111/j.1600-079X.2006.00407.x – ident: e_1_2_7_32_1 doi: 10.1111/j.1600-079X.2005.00282.x – ident: e_1_2_7_5_1 doi: 10.1002/(SICI)1097-0215(20000415)86:2<151::AID-IJC1>3.0.CO;2-0 – ident: e_1_2_7_2_1 doi: 10.1289/ehp.95103608 – volume: 25 start-page: 539 year: 2009 ident: e_1_2_7_19_1 article-title: The protective effect of melatonin on auditory cortex toxicity induced by cis‐platinum publication-title: Zhongguo Ying Yong Sheng Li Xue Za Zhi contributor: fullname: Huang MD – ident: e_1_2_7_22_1 doi: 10.1111/jpi.12070 – ident: e_1_2_7_13_1 doi: 10.1016/j.reprotox.2006.09.005 – ident: e_1_2_7_29_1 doi: 10.1016/j.ejphar.2014.12.002 – ident: e_1_2_7_41_1 doi: 10.1034/j.1600-079X.2000.290303.x – ident: e_1_2_7_18_1 doi: 10.1111/jpi.12360 – ident: e_1_2_7_57_1 doi: 10.1093/molehr/gat004 – ident: e_1_2_7_59_1 doi: 10.1083/jcb.201112094 |
SSID | ssj0008886 |
Score | 2.525726 |
Snippet | Bisphenol A (BPA) has been reported to adversely affect the mammalian reproductive system in both sexes. However, the underlying mechanisms regarding how BPA... Abstract Bisphenol A (BPA) has been reported to adversely affect the mammalian reproductive system in both sexes. However, the underlying mechanisms regarding... |
SourceID | proquest crossref pubmed wiley |
SourceType | Aggregation Database Index Database Publisher |
StartPage | np |
SubjectTerms | Animals Benzhydryl Compounds - toxicity Bisphenol A Female fertilization Fertilization - drug effects Juno Male Meiosis - drug effects melatonin Melatonin - pharmacology Metalloproteases - metabolism Mice Mice, Inbred ICR oocyte maturation Oocytes - metabolism Oocytes - pathology ovastacin Phenols - toxicity Receptors, Cell Surface - metabolism Sperm-Ovum Interactions - drug effects Spindle Apparatus - metabolism Spindle Apparatus - pathology spindle assembly Zona Pellucida - metabolism Zona Pellucida - pathology Zona Pellucida Glycoproteins - metabolism |
Title | Melatonin protects oocyte quality from Bisphenol A‐induced deterioration in the mouse |
URI | https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fjpi.12396 https://www.ncbi.nlm.nih.gov/pubmed/28178360 https://search.proquest.com/docview/1866692483 https://search.proquest.com/docview/1888979028 |
Volume | 62 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3NTuMwEB6hctkL_7vb5UfeFUJ7SZXGTuKIUwtULFJXCIHoYaXIjh2pQptWtBzKiUfgGXkSZpykUFa7WnHLwXHszIz9zXjmM8B-qITIgyDzgjixnrBSeLodaM9y3_h5GCXCcXf2f0anV-JsEA6W4LCuhSn5IeYBN7IMt16TgSs9eW3k42ELl92E6LaJSI8A0cULdRR6dlFJwRl43E9kxSrksnjqNxf3oj8A5iJedRtObxV-1UMt80xuWndT3cru37A4vnMua7BSAVHWKTVnHZZssQGbnQKd8N8zdsBcaqiLuW_CdZ9S5ihwyypehwkbjbLZ1LKyKHPGqEyFdYcTShkbYbdPD4_o7aPeGGYo42ZYqRrDPhBzMoo42C246p1cHp161Y0MXsZDGXmRksaojCNQklmcBEYqaXOEgHnbGm4tJ_o4tHjlx4Zu_tRCc0Nn-36ihI0V_wiNYlTYz8AsesAcsVOWayVi7CxpSyNDbGWsxk2yCd9q2aTjkngjnTss42HqflcTvtZSS9Es6KxDFRYnkBKPX4S-peT_aiNlEhN9TRM-lSKffyqQbVff0oTvTnB_H0N6dv7DPXz5_6bb8CEgeOAygHagMb29s7sIbqZ6D5Y73eNub89p8zNIR_df |
link.rule.ids | 315,786,790,1382,27955,27956,46327,46751 |
linkProvider | Wiley-Blackwell |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT-MwEB6x5cBeeD_K04sQ4pIqjZ3EkbjwVHkUoRUILihyYkeqEGkF5VBO_AR-I7-EGSfpwiLQam85OI6dmbG_Gc98BtjwlRCZ56WOF0bGEUYKJ2l6iWO4q93MDyJhuTvbZ0HrUhxf-9cjsF3VwhT8EMOAG1mGXa_JwCkg_d7Ke50GrrtR8ANG0dx9Msv933_Io9C3CwoSTs_hbiRLXiGbx1O9-nE3-gQxPyJWu-UcTsBNNdgi0-S28dhPGunTXzyO_zubSRgvsSjbKZRnCkZMPg0zOzn64XcDtslsdqgNu8_AVZuy5ih2y0pqhwfW7aaDvmFFXeaAUaUK2-08UNZYF7t9fX5Bhx9VRzNNSTedUtsY9oGwk1HQwczC5eHBxV7LKS9lcFLuy8AJlNRapRyxkkzDyNNSSZMhCsyaRnNjODHIodErN9R0-WciEq7peN-NlDCh4nNQy7u5WQBm0AnmCJ_SLFEixM6iptTSx1baJLhP1mG9Ek7cK7g34qHP0uvE9nfV4Vclthgtg447VG5wAjFR-QXoXkr-XRspo5AYbOowX8h8-ClPNm2JSx22rOS-HkN8fH5kHxb_vekajLUu2qfx6dHZyRL89Agt2ISgZaj17x_NCmKdfrJqVfoN9PL6DQ |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LS8QwEB58gHjx_VifUUS8dOkmaZviaX0svhFR9CCUtElhEbuL7h7Wkz_B3-gvcZK26wtFvPWQpklnJvlmMvMFYMOTnKeUJg4NQu1wLbgT12jsaOYqN_X8kFvuztMz_-CKH914NwOwXdbC5PwQ_YCbsQy7XhsDb6v0o5G3m1VcdkN_EIa5z6jxvPYu3rmj0LXzcw5O6jA3FAWtkE3jKV_9vBl9Q5ifAavdcRrjcFuONU80uat2O3E1efpC4_jPyUzAWIFEST1XnUkY0NkUTNcz9MLve2ST2NxQG3SfhutTkzNnIrekIHZ4JK1W0utokldl9oipUyE7zUeTM9bCbl-fX9DdR8VRRJmUm2ahawT7QNBJTMhBz8BVY_9y98AprmRwEuYJ3_GlUEomDJGSSIKQKiGFThEDpjWtmNbM8MehyUs3UObqz5jHTJnDfTeUXAeSzcJQ1sr0PBCNLjBKjSVpLHmAnYU1oYSHrZSOcZeswHopm6idM29EfY-l3Yzs76rAWim1CO3CHHbITOMEIkPk56NzKdhvbYQIA8NfU4G5XOT9T1FRswUuFdiygvt5DNHR-aF9WPh701UYOd9rRCeHZ8eLMEoNVLDZQEsw1Hno6mUEOp14xSr0GxSu-Lw |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Melatonin+protects+oocyte+quality+from+Bisphenol+A-induced+deterioration+in+the+mouse&rft.jtitle=Journal+of+pineal+research&rft.au=Zhang%2C+Mianqun&rft.au=Dai%2C+Xiaoxin&rft.au=Lu%2C+Yajuan&rft.au=Miao%2C+Yilong&rft.date=2017-04-01&rft.eissn=1600-079X&rft.volume=62&rft.issue=3&rft_id=info:doi/10.1111%2Fjpi.12396&rft.externalDBID=NO_FULL_TEXT |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0742-3098&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0742-3098&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0742-3098&client=summon |