Association Between Shortened Leukocyte Telomere Length and Cardiometabolic Outcomes: Systematic Review and Meta-Analysis

• Published in: Circulation. Cardiovascular genetics Vol. 8; no. 1; pp. 82 - 90
• Main Authors: D’Mello, Matthew J.J., Ross, Stephanie A., Briel, Matthias, Anand, Sonia S., Gerstein, Hertzel, Paré, Guillaume
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 01.02.2015
• Subjects: Aging - metabolism; Aging - pathology; Cellular Senescence; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - pathology; Humans; Leukocytes - metabolism; Leukocytes - pathology; Myocardial Infarction - metabolism; Myocardial Infarction - pathology; Stroke - metabolism; Stroke - pathology; Telomere - metabolism; Telomere Homeostasis; diabetes mellitus, type 2; aging; stroke; myocardial infarction

BACKGROUND—Telomeres are repetitive, gene-poor regions that cap the ends of DNA and help maintain chromosomal integrity. Their shortening is caused by inflammation and oxidative stress within the cellular environment and ultimately leads to cellular senescence. Shortened leukocyte telomere length is...