Preparation of an Amino Acid Intermediate for the Dipeptidyl Peptidase IV Inhibitor, Saxagliptin, using a Modified Phenylalanine Dehydrogenase

• Published in: Advanced synthesis & catalysis Vol. 349; no. 8-9; pp. 1369 - 1378
• Main Authors: Hanson, Ronald L., Goldberg, Steven L., Brzozowski, David B., Tully, Thomas P., Cazzulino, Dana, Parker, William L., Lyngberg, Olav K., Vu, Truc C., Wong, Michael K., Patel, Ramesh N.
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 04.06.2007; WILEY‐VCH Verlag; Wiley
• Subjects: amino acids; Chemistry; Chemistry, Applied; Chemistry, Organic; enzyme catalysis; phenylalanine dehydrogenase; Physical Sciences; reductive amination; Saxagliptin; Science & Technology; FORMATE DEHYDROGENASE; METHANOL; reductive amination; phenylalanine dehydrogenase; amino acids; enzyme catalysis; PICHIA-PASTORIS; Saxagliptin; THERMOACTINOMYCES-INTERMEDIUS

The non‐proteinogenic amino acid 2‐(3‐hydroxy‐1‐adamantyl)‐(2S)‐aminoethanoic acid [2, (S)‐3‐hydroxyadamantylglycine], is a key intermediate required for the synthesis of Saxagliptin, a dipeptidyl peptidase IV inhibitor under development for treatment of type 2 diabetes mellitus. Keto acid 2‐(3‐hydr...