Structural, functional, and symptom relations in painful distal symmetric polyneuropathies: a systematic review

• Published in: Pain (Amsterdam) Vol. 160; no. 2; pp. 286 - 297
• Main Authors: Karlsson, Pall, Hincker, Alexander M., Jensen, Troels Staehelin, Freeman, Roy, Haroutounian, Simon
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer 01.02.2019
• Subjects: Animals; Humans; Nerve Fibers - pathology; Nerve Fibers - physiology; Neurologic Examination; Polyneuropathies - diagnosis; Polyneuropathies - physiopathology; Psychophysics; Skin - innervation; Skin - pathology

The diagnosis of distal symmetric polyneuropathies (DSPs) relies on the presenting symptomatology and neurological sensory examination, supported by objectively quantified structural and functional changes in sensory nerves. Although these separate components have important diagnostic utility, the a...