β‐Catenin regulation of farnesoid X receptor signaling and bile acid metabolism during murine cholestasis

• Published in: Hepatology (Baltimore, Md.) Vol. 67; no. 3; pp. 955 - 971
• Main Authors: Thompson, Michael D., Moghe, Akshata, Cornuet, Pamela, Marino, Rebecca, Tian, Jianmin, Wang, Pengcheng, Ma, Xiaochao, Abrams, Marc, Locker, Joseph, Monga, Satdarshan P., Nejak‐Bowen, Kari
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health, Inc 01.03.2018
• Subjects: Animals; beta Catenin - metabolism; Bile; Bile acids; Bile Acids and Salts - metabolism; Bile ducts; Catenin; Cholestasis; Cholestasis - metabolism; Fibrosis; Hepatology; Liver - metabolism; Liver - pathology; Liver diseases; Localization; Mice; Mice, Knockout; Nuclear transport; Receptors, Cytoplasmic and Nuclear - metabolism; Rodents; Signal Transduction; Wnt protein

Cholestatic liver diseases result from impaired bile flow and are characterized by inflammation, atypical ductular proliferation, and fibrosis. The Wnt/β‐catenin pathway plays a role in bile duct development, yet its role in cholestatic injury remains indeterminate. Liver‐specific β‐catenin knockout...