Hydroxylation of deoxycorticosterone by Bacillus cereus, strain T

• Published in: Archives of biochemistry and biophysics Vol. 114; no. 1; pp. 166 - 177
• Main Authors: Wilson, John E., Ober, R.E., Vestling, C.S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.1966
• Subjects: Bacillus cereus - metabolism; Carbon Monoxide; Cyanides; Desoxycorticosterone - metabolism; Electron Transport Complex IV - metabolism; Methylene Blue; Mixed Function Oxygenases - metabolism

Deoxycorticosterone (DOC) is monohydroxylated by Bacillus cereus, strain T, to give the 6β-, 14α-, 15α-, and 15β-hydroxy isomers in the approximate ratios of 2:3:2:2. No evidence for metabolism of DOC beyond the monohydroxylated stage has been found. The steroid hydroxylating system is not dependent...