An automated, high-capacity method for measuring jumping latencies on a hot-plate

• Published in: Journal of pharmacological methods Vol. 10; no. 1; p. 13
• Main Authors: O'Neill, K A, Courtney, C, Rankin, R, Weissman, A
• Format: Journal Article
• Language: English
• Published: United States 01.08.1983
• Subjects: Analgesics - pharmacology; Animals; Drug Evaluation, Preclinical - instrumentation; Male; Mice; Microcomputers; Morphine - pharmacology; Naloxone - pharmacology; Reaction Time - drug effects; Temperature; Time Factors

A high-capacity automated apparatus for conducting analgetic screening in mice with an entirely objective endpoint is described. A thermostatically controlled hot-plate apparatus is interfaced with a minicomputer for recording jump latencies, which appear to reflect an affective component of pain. I...