The effect of nutritional and thyroid state on the distribution of fatty acids between oxidation and esterification in isolated rat hepatocytes

• Published in: Biochimica et biophysica acta Vol. 793; no. 1; pp. 1 - 9
• Main Authors: Stakkestad, Jacob A., Lund, Henrik
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 27.03.1984
• Subjects: Animals; Esters; Fasting; Fatty acid metabolism; Fatty Acids - metabolism; Giycerol; Glycerol - pharmacology; Glycerophosphates - metabolism; Liver - metabolism; Male; Malonyl-CoA; Nutrition; Oxidation-Reduction; Palmitic Acid; Palmitic Acids - metabolism; Rats; Thyroid Gland - physiology; Thyroid state; α-Glycerophosphate; Giycerol; Fatty acid metabolism; Nutrition; Thyroid state; Malonyl-CoA; α-Glycerophosphate

Small amounts of glycerol (0.25 mM) simultaneously decrease oxidation and increase esterification of fatty acids in isolated rat hepatocytes, mainly by raising the intracellular concentration of α-glycerophosphate. These effects were obtained in all thyroid states as well as in the fed and fasted st...