Desialylated low density lipoprotein - naturally occurring modified lipoprotein with atherogenic potency

• Published in: Atherosclerosis Vol. 86; no. 2; pp. 153 - 161
• Main Authors: Orekhov, Alexander N., Tertov, Vladimir V., Mukhin, Dmitry N.
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.02.1991
• Subjects: Adult; Aorta - metabolism; Arteriosclerosis - metabolism; Atherogenicity; Atherosclerosis; Cells, Cultured; Cholesterol accumulation; Coronary Artery Disease - blood; Cultured cells; Female; Humans; Lipid Metabolism; Lipoproteins, LDL - blood; Lipoproteins, LDL - chemistry; Lipoproteins, LDL - physiology; Low density lipoprotein; Male; Middle Aged; Modified lipoprotein; N-Acetylneuraminic Acid; Neuraminidase; Sialic acid; Sialic Acids - analysis; Sialic acid; Atherosclerosis; Neuraminidase; Cholesterol accumulation; Cultured cells; Modified lipoprotein; Low density lipoprotein; Atherogenicity

We have recently established that low density lipoprotein (LDL) of most patients with coronary atherosclerosis differs from the LDL of most healthy subjects by its ability to cause primary atherosclerotic changes, i.e. the accumulation of intracellular cholesterol in the cells of smooth muscle origi...