Differential effects of polyunsaturated fatty acids on cell growth and differentiation of premonocytic U937 cells

• Published in: Biochimica et biophysica acta Vol. 1266; no. 2; pp. 179 - 185
• Main Authors: Obermeier, H., Hrboticky, N., Sellmayer, A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 28.04.1995
• Subjects: Antigens, CD - analysis; Antigens, Differentiation, Myelomonocytic - analysis; CD11 Antigens - analysis; Cell differentiation; Cell Differentiation - drug effects; Cell Division - drug effects; Cell growth; Cell Line - drug effects; Fatty Acids, Unsaturated - pharmacology; Humans; Lipopolysaccharide Receptors; Monocytes - drug effects; Phagocytosis - drug effects; Phospholipids - analysis; Polyunsaturated fatty acid; Premanocytic cell (U937); Triglycerides - analysis; Polyunsaturated fatty acid; Cell growth; Cell differentiation; Premanocytic cell (U937)

The effect of long chain polyunsaturated fatty acids (PUFA) on cell growth and differentiation was assessed in human premonocytic U937 cells. Addition of either 10 μM arachidonic acid (AA, 20:4n-6), eicosapentaenoic acid (EPA, 20:5n-3) or docosahexaenoic acid (DHA, 22:6n-3) resulted in the rapid inc...