Selective targeting of magnetic albumin microspheres to the Yoshida sarcoma: Ultrastructural evaluation of microsphere disposition

• Published in: European journal of cancer & clinical oncology Vol. 19; no. 1; pp. 141 - 147
• Main Authors: Widder, Kenneth J., Marino, Philip A., Morris, Robert M., Howard, Donald P., Poore, Gerald A., Senyei, Andrew E.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 1983
• Subjects: Animals; Antineoplastic Agents - administration & dosage; Cytoplasm - ultrastructure; Doxorubicin - administration & dosage; Magnetics; Microscopy, Electron; Microspheres; Rats; Sarcoma, Yoshida - drug therapy; Sarcoma, Yoshida - ultrastructure; Serum Albumin

Magnetic albumin microspheres (1 μ m average diameter) were selectively targeted to subcutaneous solid Yoshida sarcoma tumors (average size 450 mm 2) in Holtzman rats. This was accomplished by placing an external magnet adjacent to the tumor while the microspheres were infused. Microspheres containe...