The use of nonmetric multidimensional scaling for the analysis of chromosomal associations

• Published in: Computers and biomedical research Vol. 13; no. 1; pp. 19 - 35
• Main Authors: Rohlf, F.James, Rodman, Toby C., Flehinger, Betty J.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.1980
• Subjects: Centromere - ultrastructure; Chromosomes, Human - ultrastructure; Chromosomes, Human, 1-3 - ultrastructure; Chromosomes, Human, 13-15 - ultrastructure; Chromosomes, Human, 16-18 - ultrastructure; Chromosomes, Human, 19-20 - ultrastructure; Chromosomes, Human, 21-22 and Y - ultrastructure; Chromosomes, Human, 4-5 - ultrastructure; Chromosomes, Human, 6-12 and X - ultrastructure; Female; Humans; Lymphocytes - cytology; Male; Mathematics; Metaphase; Models, Biological; Sex Chromosomes - ultrastructure

Methods are presented for the statistical analysis of the patterns of association among metaphase chromosomes in the conventional cytogenetic preparation of human peripheral lymphocytes. For each cell midpoints of the p and q ends and the centromere of each chromosome were digitized, these coordinat...