The molecular basis of prostate cancer

Cancer involves accumulation of genetic alterations. This review highlights the alterations in control pathways for cell division, development, DNA repair, angiogenesis and cell death that are believed to be key players in the development of prostate cancer.

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Bibliographic Details
Published inBritish journal of hospital medicine (London, England : 2005) Vol. 66; no. 11; p. 612
Main Authors Olsson, A Yvonne, Cooper, Colin S
Format Journal Article
LanguageEnglish
Published England 01.11.2005
Subjects
Apoptosis - physiology
DNA Repair - physiology
Hedgehog Proteins
Histones - metabolism
Humans
Male
Mitosis - physiology
Oncogene Proteins - metabolism
Phosphatidylinositol 3-Kinases - metabolism
Prostatic Neoplasms - genetics
Prostatic Neoplasms - metabolism
Prostatic Neoplasms - pathology
Proto-Oncogene Proteins c-akt - metabolism
Receptors, Androgen - physiology
Retinoblastoma Protein - metabolism
Trans-Activators - metabolism
Transcription Factors - metabolism
Wnt Proteins - metabolism
Zinc Finger Protein GLI1
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Summary:Cancer involves accumulation of genetic alterations. This review highlights the alterations in control pathways for cell division, development, DNA repair, angiogenesis and cell death that are believed to be key players in the development of prostate cancer.
ISSN:1750-8460
DOI:10.12968/hmed.2005.66.11.20021