The interaction of fibronectin (fn) with native, polymeric collagen (collagen fibres): comparison with von Willebrand factor (vWf)-binding by collagen

• Published in: Thrombosis and haemostasis Vol. 61; no. 3; p. 378
• Main Authors: Cockburn, C G, Fitzsimmons, C M, Barnes, M J
• Format: Journal Article
• Language: English
• Published: Germany 30.06.1989
• Subjects: Amino Acids - metabolism; Animals; Cattle; Collagen - metabolism; Fibrin Fibrinogen Degradation Products - metabolism; Fibronectins - metabolism; Humans; Iodine Radioisotopes; Polymers; Protein Binding; Protein Denaturation; von Willebrand Factor - metabolism

The binding of fn to collagen (type I) fibres has been found to resemble that of vWf in the following respects: Binding is rapid, specific, saturable, similar at 4 and 37 degrees C, and reduced by increasing ionic strength. Binding is not inhibited by native, monomeric collagen, suggesting a multiva...