A genetic variant in cytoskeleton motors amplifies susceptibility to leukoaraiosis in hypertensive smokers: gene-environmental interactions behind vascular white matter demyelinization

• Published in: Journal of molecular neuroscience Vol. 33; no. 2; pp. 173 - 179
• Main Authors: Szolnoki, Zoltan, Kondacs, Andras, Mandi, Yvette, Somogyvari, Ferenc
• Format: Journal Article
• Language: English
• Published: United States Springer Nature B.V 01.10.2007
• Subjects: Aged; Aged, 80 and over; Clinical medicine; Cytoskeleton - metabolism; Female; Genetic Predisposition to Disease; Genetics; Humans; Hypertension; Kinesin - genetics; Leukoaraiosis - genetics; Leukoaraiosis - pathology; Male; Medical imaging; Medical research; Middle Aged; Models, Theoretical; Polymorphism, Single Nucleotide; Risk Factors; Smoking

One of the most frequent causes of an age-associated cognitive decline is the vascular white matter demyelinization of the brain referred to as leukoaraiosis (LA). The wide range of severity of the cognitive decline caused by LA can have numerous deleterious effects on the quality of life, leading o...