Effects of oxygen on metabolic and secretory activities of βTC3 cells

• Published in: Biochimica et biophysica acta Vol. 1291; no. 2; pp. 163 - 166
• Main Authors: Papas, K.K., Long, R.C., Constantinidis, I., Sambanis, A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 24.10.1996
• Subjects: Animals; Anoxia; Bioartificial pancreas; Cell Hypoxia; Glucose - metabolism; Glucose - pharmacology; Hypoxia; Insulin - metabolism; Insulin Secretion; Insulinoma; Islets of Langerhans - drug effects; Islets of Langerhans - metabolism; Lactic Acid - biosynthesis; Mice; Oxygen - pharmacology; Tumor Cells, Cultured; βTC3; Hypoxia; Bioartificial pancreas; Anoxia; βTC3; Insulin secretion

We have investigated the rates of glucose consumption, lactate production and insulin secretion by mouse insulinoma βTC3 cells exposed to high glucose and oxygen concentrations in the range of 132 mmHg (normoxia) to 0 mmHg (anoxia). The rates of glucose consumption and lactate production, and the yi...