Fatty acids in plasma phospholipids and cholesterol esters from identical twins concordant and discordant for schizophrenia

The fatty acid compositions of plasma phospholipids and cholesterol esters were measured in 18 pairs of twins discordant for schizophrenia and 20 pairs concordant for schizophrenia. In the twins discordant for schizophrenia the only significant abnormalities were elevations of adrenic (22:4n-6) and...

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Published inSchizophrenia research Vol. 6; no. 1; pp. 1 - 7
Main Authors Bates, C., Horrobin, D.F., Ells, K.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.12.1991
Subjects
Adrenic acid
Adult
Cholesterol Esters - blood
Diseases in Twins - genetics
Diseases in Twins - psychology
Essential fatty acids
Fatty Acids - blood
Female
Humans
Linoleic acid
Male
Neurocognitive Disorders - blood
Neurocognitive Disorders - genetics
Phospholipids - blood
Schizophrenia
Schizophrenia - blood
Schizophrenia - genetics
Schizophrenic Psychology
Twins
Twins, Monozygotic - genetics
Twins, Monozygotic - psychology
Schizophrenia
Twins
Essential fatty acids
Adrenic acid
Linoleic acid
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Abstract The fatty acid compositions of plasma phospholipids and cholesterol esters were measured in 18 pairs of twins discordant for schizophrenia and 20 pairs concordant for schizophrenia. In the twins discordant for schizophrenia the only significant abnormalities were elevations of adrenic (22:4n-6) and docosapentaenoic (22:5n-6) acids in the schizophrenic twins. These fatty acids have also recently been reported to be elevated in brains from schizophrenics. The twins concordant for schizophrenia showed many differences from the normal discordant twins. 22:4n-6 and 22:5n-6 were even more abnormal than in the schizophrenic discordant twins. In addition, linoleic acid was significantly reduced, an abnormality which has been found consistently in other schizophrenic populations. These observations are consistent with the concept that unsaturated fat metabolism may be abnormal in schizophrenia.
AbstractList The fatty acid compositions of plasma phospholipids and cholesterol esters were measured in 18 pairs of twins discordant for schizophrenia and 20 pairs concordant for schizophrenia. In the twins discordant for schizophrenia the only significant abnormalities were elevations of adrenic (22:4n-6) and docosapentaenoic (22:5n-6) acids in the schizophrenic twins. These fatty acids have also recently been reported to be elevated in brains from schizophrenics. The twins concordant for schizophrenia showed many differences from the normal discordant twins. 22:4n-6 and 22:5n-6 were even more abnormal than in the schizophrenic discordant twins. In addition, linoleic acid was significantly reduced, an abnormality which has been found consistently in other schizophrenic populations. These observations are consistent with the concept that unsaturated fat metabolism may be abnormal in schizophrenia.
Author Bates, C.
Ells, K.
Horrobin, D.F.
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Issue 1
Keywords Schizophrenia
Twins
Essential fatty acids
Adrenic acid
Linoleic acid
Language English
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Snippet The fatty acid compositions of plasma phospholipids and cholesterol esters were measured in 18 pairs of twins discordant for schizophrenia and 20 pairs...
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SubjectTerms Adrenic acid
Adult
Cholesterol Esters - blood
Diseases in Twins - genetics
Diseases in Twins - psychology
Essential fatty acids
Fatty Acids - blood
Female
Humans
Linoleic acid
Male
Neurocognitive Disorders - blood
Neurocognitive Disorders - genetics
Phospholipids - blood
Schizophrenia
Schizophrenia - blood
Schizophrenia - genetics
Schizophrenic Psychology
Twins
Twins, Monozygotic - genetics
Twins, Monozygotic - psychology
Title Fatty acids in plasma phospholipids and cholesterol esters from identical twins concordant and discordant for schizophrenia
URI https://dx.doi.org/10.1016/0920-9964(91)90014-I
https://www.ncbi.nlm.nih.gov/pubmed/1786231
https://search.proquest.com/docview/72642644
Volume 6
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