Apoptotic effect of fludarabine is independent of expression of IAPs in B-cell chronic lymphocytic leukemia

• Published in: Apoptosis (London) Vol. 11; no. 2; pp. 277 - 285
• Main Authors: Silva, K L, Vasconcellos, D V, Castro, E D de Paula, Coelho, A M, Linden, R, Maia, R C
• Format: Journal Article
• Language: English
• Published: Netherlands Springer Nature B.V 01.02.2006
• Subjects: Adult; Aged; Annexin A5 - metabolism; Antineoplastic Agents - pharmacology; Apoptosis; Apoptosis - drug effects; Cells, Cultured; Cytotoxicity Tests, Immunologic; Female; Humans; Immunohistochemistry; Inhibitor of Apoptosis Proteins - genetics; Inhibitor of Apoptosis Proteins - metabolism; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy; Leukemia, Lymphocytic, Chronic, B-Cell - pathology; Lymphocytes; Male; Middle Aged; Vidarabine - analogs & derivatives; Vidarabine - pharmacology

Despite the efficiency of fludarabine in the induction of clinical responses in B-cell chronic lymphocytic leukemia (B-CLL) patients, resistance to this drug has been documented. The present study tested whether resistance to fludarabine is related to the expression of inhibitor of apoptosis protein...