Combined high-performance liquid chromatography and radioimmunoassay for ceruletide and its metabolites in dog plasma and urine

• Published in: Journal of pharmaceutical and biomedical analysis Vol. 12; no. 3; p. 413
• Main Authors: Kominami, G, Okabe, H, Imoda, K, Mizojiri, K
• Format: Journal Article
• Language: English
• Published: England 01.03.1994
• Subjects: Animals; Ceruletide - administration & dosage; Ceruletide - blood; Ceruletide - pharmacokinetics; Ceruletide - urine; Chromatography, High Pressure Liquid; Dogs; Injections, Intramuscular; Peptide Fragments - blood; Peptide Fragments - urine; Radioimmunoassay; Reproducibility of Results

A combined high-performance liquid chromatographic (HPLC) and competitive radioimmunoassay (RIA) method for ceruletide (CLT), an analogue of cholecystokinin-8, was developed to investigate the behaviour of CLT in dogs. Dog plasma samples after administration of CLT were deproteinized and separated b...