Chromosomal abnormalities in lymphoid tumours: mechanism and role in tumour pathogenesis

Chromosomal abnormalities have been the focus of study recently, after the discovery of oncogenes at the junctions of translocations in Burkitt's lymphoma and the Philadelphia chromosome in chronic myelogenous leukaemia. Can these findings be extrapolated to other, less consistently occurring a...

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Published inTrends in genetics Vol. 4; no. 11; pp. 300 - 304
Main Authors Rabbitts, T.H., Boehm, T., Mengle-Gaw, L.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.11.1988
Subjects
Chromosome Aberrations - complications
Chromosome Aberrations - genetics
Chromosome Disorders
Chromosome Inversion
Chromosomes, Human, Pair 11 - ultrastructure
Chromosomes, Human, Pair 14 - ultrastructure
Humans
Leukemia, T-Cell - etiology
Leukemia, T-Cell - genetics
Oncogenes
Receptors, Antigen - genetics
Translocation, Genetic
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Abstract Chromosomal abnormalities have been the focus of study recently, after the discovery of oncogenes at the junctions of translocations in Burkitt's lymphoma and the Philadelphia chromosome in chronic myelogenous leukaemia. Can these findings be extrapolated to other, less consistently occurring abnormalities? To analyse this question, we specifically discuss chromosomal abnormalities involving the human T-cell receptor δ/α locus. We discuss the mechanism for the formation of these chromosomal aberrations, and their possible significance for the pathogenesis of T-cell tumours. Current evidence suggests that some of these aberrations are involved in tumour pathogenesis while others are not.
AbstractList Chromosomal abnormalities have been the focus of study recently, after the discovery of oncogenes at the junctions of translocations in Burkitt's lymphoma and the Philadelphia chromosome in chronic myelogenous leukaemia. Can these findings be extrapolated to other, less consistently occurring abnormalities? To analyse this question, we specifically discuss chromosomal abnormalities involving the human T-cell receptor δ/α locus. We discuss the mechanism for the formation of these chromosomal aberrations, and their possible significance for the pathogenesis of T-cell tumours. Current evidence suggests that some of these aberrations are involved in tumour pathogenesis while others are not.
Author Mengle-Gaw, L.
Rabbitts, T.H.
Boehm, T.
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SubjectTerms Chromosome Aberrations - complications
Chromosome Aberrations - genetics
Chromosome Disorders
Chromosome Inversion
Chromosomes, Human, Pair 11 - ultrastructure
Chromosomes, Human, Pair 14 - ultrastructure
Humans
Leukemia, T-Cell - etiology
Leukemia, T-Cell - genetics
Oncogenes
Receptors, Antigen - genetics
Translocation, Genetic
Title Chromosomal abnormalities in lymphoid tumours: mechanism and role in tumour pathogenesis
URI https://dx.doi.org/10.1016/0168-9525(88)90106-0
https://www.ncbi.nlm.nih.gov/pubmed/3070852
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Volume 4
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