Effects of insulin and insulin-like growth factors on proliferation of rat ovarian theca-interstitial cells

• Published in: Biology of reproduction Vol. 56; no. 4; pp. 891 - 897
• Main Authors: DULEBA, A. J, SPACZYNSKI, R. Z, OLIVE, D. L, BEHRMAN, H. R
• Format: Journal Article
• Language: English
• Published: Madison, WI Society for the Study of Reproduction 01.04.1997
• Subjects: 3-Hydroxysteroid Dehydrogenases - metabolism; Analysis of Variance; Animals; Biological and medical sciences; Cell Division - drug effects; Cells, Cultured; DNA - biosynthesis; Female; Fundamental and applied biological sciences. Psychology; Hormone metabolism and regulation; Insulin - pharmacology; Insulin-Like Growth Factor Binding Proteins - metabolism; Insulin-Like Growth Factor I - pharmacology; Insulin-Like Growth Factor II - pharmacology; Mammalian female genital system; Ovary - cytology; Ovary - drug effects; Ovary - metabolism; Rats; Rats, Sprague-Dawley; Sexual Maturation; Theca Cells - cytology; Theca Cells - drug effects; Theca Cells - metabolism; Thymidine - metabolism; Tritium; Vertebrates: reproduction; Cell proliferation; Pancreatic hormone; Theca folliculi; Rat; Rodentia; Insulin like growth factor 1; Insulin like growth factor 2; In vitro; Insulin; Ovary; Interstitial cell; Vertebrata; Mammalia; Female genital system; Female; Differentiation; Ovarian follicle

Hyperplasia of the theca-interstitial (T-I) compartment, such as observed in polycystic ovary syndrome, is associated with ovarian dysfunction. Yet the mechanisms regulating proliferation of T-I cells are virtually unknown. This study was an investigation of the effects of insulin and insulin-like g...