Neonatal capsaicin and thermal nociception: a paradox

Thermal and mechanical nociceptive thresholds and somato-visceral reflexes have been studied in normal rats and in rats treated neonatally with capsaicin. Mechanical nociceptive thresholds were increased in capsaicin treated rats whereas thermal nociceptive thresholds remained unchanged. In contrast...

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Bibliographic Details
Published inBrain research Vol. 215; no. 1-2; p. 414
Main Authors Cervero, F, McRitchie, H A
Format Journal Article
LanguageEnglish
Published Netherlands 29.06.1981
Subjects
Animals
Animals, Newborn
Blood Pressure
Capsaicin - pharmacology
Fatty Acids, Unsaturated - pharmacology
Gastrointestinal Motility
Hot Temperature
Nociceptors - drug effects
Nociceptors - physiology
Pain - physiopathology
Rats
Skin Physiological Phenomena
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Summary:Thermal and mechanical nociceptive thresholds and somato-visceral reflexes have been studied in normal rats and in rats treated neonatally with capsaicin. Mechanical nociceptive thresholds were increased in capsaicin treated rats whereas thermal nociceptive thresholds remained unchanged. In contrast, somato-visceral reflexes evoked by thermal noxious stimulation of the skin could not be elicited in capsaicin treated rats whereas mechanical noxious stimulation was effective in evoking visceral reflexes.
ISSN:0006-8993
DOI:10.1016/0006-8993(81)90527-8