Carbon disulfide-induced changes in cytoskeleton protein content of rat cerebral cortex

• Published in: Neurochemical research Vol. 31; no. 1; pp. 71 - 79
• Main Authors: Song, Fuyong, Yu, Sufang, Zhao, Xiulan, Zhang, Cuili, Xie, Keqin
• Format: Journal Article
• Language: English
• Published: United States Springer Nature B.V 01.01.2006
• Subjects: Actins - metabolism; Animals; Body Weight; Carbon Disulfide - administration & dosage; Carbon Disulfide - pharmacology; Carbon Disulfide - toxicity; Cerebral Cortex - cytology; Cerebral Cortex - drug effects; Cerebral Cortex - metabolism; Cytoskeletal Proteins - metabolism; Male; Neurofilament Proteins - metabolism; Rats; Rats, Wistar; Subcellular Fractions - metabolism; Tubulin - metabolism

To investigate the mechanism of carbon disulfide-induced neuropathy, male wistar rats were administrated by gavage at dosage of 300 or 500 mg/kg carbon disulfide, five times per week for 12 weeks. By the end of the exposure, the animals produced a slight or moderate level of neurological deficits, r...