The formation of N-alkylprotoporphyrin IX and destruction of cytochrome P-450 in the liver of rats after treatment with 3,5-diethoxycarbonyl-1,4-dihydrocollidine and its 4-ethyl analog
The effects of two porphyrogenic agents, 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) and 3,5-diethoxycarbonyl-2,6-dimethyl-4-ethyl-1,4-dihydropyridine (DDEP), have been studied in rats. The administration of these compounds leads to the formation and accumulation in the liver of N-methylprotopor...
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Published in | Archives of biochemistry and biophysics Vol. 218; no. 1; pp. 220 - 224 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
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Elsevier Inc
01.10.1982
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Abstract | The effects of two porphyrogenic agents, 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) and 3,5-diethoxycarbonyl-2,6-dimethyl-4-ethyl-1,4-dihydropyridine (DDEP), have been studied in rats. The administration of these compounds leads to the formation and accumulation in the liver of
N-methylprotoporphyrin IX and
N-ethylprotoporphyrin IX, respectively. In each case, the alkyl group of the porphyrin is derived from the 4-alkyl group of the porphyrogenic chemical. Each
N-alkylporphyrin is a potent inhibitor of protoheme ferrolyase (EC 4.99.1.1) (ferrochelatase) activity.
N-Methylprotoporphyrin IX is somewhat more potent than
N-ethylprotoporphyrin IX as an inhibitor of ferrochelatase activity
in vitro. However, more
N-ethylprotoporphyrin IX accumulates in rat liver than does the
N-methyl analog. Since alkylporphyrins are formed during the catabolism of heme (or hemoprotein), the effects of DDC and DDEP on hepatic microsomal cytochrome
P-450 were also studied. Whereas DDC treatment led to only a slight decrease in cytochrome
P-450 levels (25%), DDEP administration led to a marked decrease (75%) in the total cytochrome
P-450 level. In phenobarbital- and 3-methylcholanthrene-treated rats, DDC administration did not alter the hepatic microsomal cytochrome
P-450 content, while administration of DDEP to either phenobarbital-treated or 3-methylcholanthrene-treated rats led to marked reduction of levels in cytochrome
P-450. Although the
N-methylprotoporphyrin IX level was not increased following DDC administration to either phenobarbital- or 3-methylcholanthrene-treated rats, there was a marked increase in
N-ethylprotoporphyrin IX accumulation in both phenobarbital- and 3-methylcholanthrene-treated rats after the administration of DDEP. These results suggest that DDC and DDEP react with different forms of rat hepatic microsomal cytochrome
P-450. |
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AbstractList | The effects of two porphyrogenic agents, 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) and 3,5-diethoxycarbonyl-2,6-dimethyl-4-ethyl-1,4-dihydropyridine (DDEP), have been studied in rats. The administration of these compounds leads to the formation and accumulation in the liver of
N-methylprotoporphyrin IX and
N-ethylprotoporphyrin IX, respectively. In each case, the alkyl group of the porphyrin is derived from the 4-alkyl group of the porphyrogenic chemical. Each
N-alkylporphyrin is a potent inhibitor of protoheme ferrolyase (EC 4.99.1.1) (ferrochelatase) activity.
N-Methylprotoporphyrin IX is somewhat more potent than
N-ethylprotoporphyrin IX as an inhibitor of ferrochelatase activity
in vitro. However, more
N-ethylprotoporphyrin IX accumulates in rat liver than does the
N-methyl analog. Since alkylporphyrins are formed during the catabolism of heme (or hemoprotein), the effects of DDC and DDEP on hepatic microsomal cytochrome
P-450 were also studied. Whereas DDC treatment led to only a slight decrease in cytochrome
P-450 levels (25%), DDEP administration led to a marked decrease (75%) in the total cytochrome
P-450 level. In phenobarbital- and 3-methylcholanthrene-treated rats, DDC administration did not alter the hepatic microsomal cytochrome
P-450 content, while administration of DDEP to either phenobarbital-treated or 3-methylcholanthrene-treated rats led to marked reduction of levels in cytochrome
P-450. Although the
N-methylprotoporphyrin IX level was not increased following DDC administration to either phenobarbital- or 3-methylcholanthrene-treated rats, there was a marked increase in
N-ethylprotoporphyrin IX accumulation in both phenobarbital- and 3-methylcholanthrene-treated rats after the administration of DDEP. These results suggest that DDC and DDEP react with different forms of rat hepatic microsomal cytochrome
P-450. |
Author | Coffman, B.L. Ingall, G. Tephly, T.R. |
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Snippet | The effects of two porphyrogenic agents, 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) and 3,5-diethoxycarbonyl-2,6-dimethyl-4-ethyl-1,4-dihydropyridine... |
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SubjectTerms | Alkylation Animals Cytochrome P-450 Enzyme System - metabolism Dicarbethoxydihydrocollidine - analogs & derivatives Dicarbethoxydihydrocollidine - pharmacology Ferrochelatase - antagonists & inhibitors Male Microsomes, Liver - enzymology Porphyrins - metabolism Protoporphyrins - metabolism Pyridines - pharmacology Rats Rats, Inbred Strains |
Title | The formation of N-alkylprotoporphyrin IX and destruction of cytochrome P-450 in the liver of rats after treatment with 3,5-diethoxycarbonyl-1,4-dihydrocollidine and its 4-ethyl analog |
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