The independent predictors of non‐alcoholic steatohepatitis and its individual histological features Insulin resistance, serum uric acid, metabolic syndrome, alanine aminotransferase and serum total cholesterol are a clue to pathogenesis and candidate targets for treatment

• Published in: Hepatology research Vol. 46; no. 11; pp. 1074 - 1087
• Main Authors: Ballestri, Stefano, Nascimbeni, Fabio, Romagnoli, Dante, Lonardo, Amedeo
• Format: Journal Article
• Language: English
• Published: Netherlands 01.10.2016
• Subjects: inflammatory grading; HOMA-IR; iron; NAFLD; fibrosis; steatosis

The diagnosis of non-alcoholic steatohepatitis (NASH) is based on the individual histological features: steatosis, lobular inflammation and ballooning. Non-alcoholic fatty liver disease (NAFLD) activity score (NAS ≥ 5) is used in clinical trials. Fibrosis dictates long-term NAFLD prognosis. Recently...