Effect of moderate obesity on glucose transport in human muscle

• Published in: Hormone and metabolic research Vol. 26; no. 4; p. 181
• Main Authors: Elton, C W, Tapscott, E B, Pories, W J, Dohm, G L
• Format: Journal Article
• Language: English
• Published: Germany 01.04.1994
• Subjects: 3-O-Methylglucose; Adolescent; Adult; Body Weight - physiology; Deoxyglucose - metabolism; Female; Glucose - metabolism; Humans; In Vitro Techniques; Insulin - pharmacology; Insulin-Like Growth Factor I - pharmacology; Insulin-Like Growth Factor II - pharmacology; Methylglucosides - metabolism; Muscles - drug effects; Muscles - metabolism; Obesity - metabolism; Rectus Abdominis - drug effects; Rectus Abdominis - metabolism
• DOI: 10.1055/s-2007-1000807
• ISSN: 0018-5043

We have shown that maximally stimulated glucose transport is reduced in in vitro incubated muscle of morbidly obese subjects. To investigate the possibility that a "threshold" of obesity exists, above which glucose transport is significantly decreased, hormone (insulin, IGF-I, or IGF-II) stimulation of glucose transport was correlated with body mass index using muscle biopsies from a group of 30 lean to obese females with BMI ranging from 16 to 40. There was a significant negative relationship between stimulation for glucose transport and BMI (R = 0.765). These data suggest there is no obesity threshold for insulin resistance in skeletal muscle but a continuous decline in glucose transport below a BMI of approximately 30 kg/m2, after which insulin and the IGFs no longer stimulate glucose transport.