Views from within and beyond: narratives of cardiac contractile dysfunction under senescence

• Published in: Endocrine Vol. 26; no. 2; p. 127
• Main Authors: Yang, Xiaoping, Sreejayan, Nair, Ren, Jun
• Format: Journal Article
• Language: English
• Published: United States 01.03.2005
• Subjects: Aged; Aging - physiology; Animals; Coronary Disease - etiology; Coronary Disease - physiopathology; Endocrine System - physiopathology; Female; Heart - physiology; Humans; Male; Myocardial Contraction - physiology; Myocytes, Cardiac - pathology; Oxidative Stress - physiology; Rats; Signal Transduction - physiology

Senescence is associated with enhanced risk of cardio-vascular diseases. It is generally considered that decline in growth hormones (such as insulin-like growth factor I), intrinsic myocardial and endothelial functions, as well as accumulation of reactive oxygen species with increased age may contri...