The role of platelet CD154 in the modulation in adaptive immunity

• Published in: Immunologic research Vol. 39; no. 1-3; pp. 185 - 193
• Main Authors: Sprague, Daniel L., Sowa, Jennifer M., Elzey, Bennett D., Ratliff, Timothy L.
• Format: Journal Article
• Language: English
• Published: United States Springer Nature B.V 01.11.2007
• Subjects: Animals; Antibody Formation; Antigen presentation; B-Lymphocytes - immunology; B-Lymphocytes - metabolism; Blood platelets; Blood Platelets - immunology; Blood Platelets - metabolism; CD40 Ligand - immunology; CD40 Ligand - metabolism; Hemostasis; Immune system; Immunity, Innate; Immunology; Lymphocyte Activation; Platelet Activation; T cell receptors; T-Lymphocytes - immunology; T-Lymphocytes - metabolism

Platelets' primary role is hemostasis. However, a growing body of research has demonstrated that platelets are integral to the initiation of an inflammatory response and are potent effector cells of the innate immune response. Activated platelets express CD154, a molecule critical to adaptive i...