Nicotinamide protects human beta cells against chemically-induced necrosis, but not against cytokine-induced apoptosis - Hoorens, A.; Pipeleers, D. (Diabetologia, 1999)
Keywords: Animals; Apoptosis - drug effects; Apoptosis - physiology; Biological and medical sciences; Cell Survival - drug effects; Cells, Cultured; Cytokines - pharmacology; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Humans; Hydrogen Peroxide - pharmacology; Interferon-gamma - pharmacology; Interleukin-1 - pharmacology; Islets of Langerhans - cytology; Islets of Langerhans - drug effects; Islets of Langerhans - pathology; Male; Medical sciences; Necrosis; Niacinamide - pharmacology; Rats; Rats, Wistar; Recombinant Proteins - pharmacology; Streptozocin - toxicity; Tumor Necrosis Factor-alpha - pharmacology; Endocrinopathy; Human; Immunopathology; Cytokine; Langerhans islet; Autoimmune disease; B-Vitamins; In vitro; Necrosis; B-Cell; Cell death; Insulin dependent diabetes; Nicotinamide; Protection; Endocrine pancreas; Apoptosis