Study of bone loss in diabetes mellitus type 1
While people with type 1 diabetes mellitus (DM) often have bone deficiency, the relation between this dificiency and the duration or control of diabetes remains controversial. To assess the possibility of such an interrelationship, we studied parameters relating to mineral metabolism (Ca, P, alkalin...
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Published in | Diabetes research and clinical practice Vol. 6; no. 3; pp. 237 - 242 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
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Ireland
Elsevier Ireland Ltd
01.04.1989
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Abstract | While people with type 1 diabetes mellitus (DM) often have bone deficiency, the relation between this dificiency and the duration or control of diabetes remains controversial. To assess the possibility of such an interrelationship, we studied parameters relating to mineral metabolism (Ca, P, alkaline phosphatase, Mg, PTH, and hydroxyproline (OHP)); bone remodeling (osteocalcin); diabetic control (HbA
1c); and radiological study of the second metacarpal of the left hand and of bone age in 87 children with type 1 DM. The mineral parameters were not abnormal among the diabetics. Diabetic children had similar levels of fasting osteocalcin as normals (10.05 ± 4.9 vs. 9.79 ± 3.34 ng/ml, mean ± SD); this did not differ by sex. The bone age fell within two standard deviations of the mean, and 9.5% of the diabetics had a bone mass deficit (less than the mean cortical thickness) greater than 2 SD. There was no correlation between osteocalcin and Ca, P, glycemia, HbA
1c, PTH, Mg, or OHP. Our results do not support any association between bone mass loss and the severity or duration of type 1 diabetes. Bone turnover, measured by serum osteocalcin, was normal. Therefore the pathogenesis of osteopenia in type 1 DM remains unclear, and requires further investigation. |
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AbstractList | While people with type 1 diabetes mellitus (DM) often have bone deficiency, the relation between this deficiency and the duration or control of diabetes remains controversial. To assess the possibility of such an interrelationship, we studied parameters relating to mineral metabolism (Ca, P, alkaline phosphatase, Mg, PTH, and hydroxyproline (OHP)); bone remodeling (osteocalcin); diabetic control (HbA1c); and radiological study of the second metacarpal of the left hand and of bone age in 87 children with type 1 DM. The mineral parameters were not abnormal among the diabetics. Diabetic children had similar levels of fasting osteocalcin as normals (10.05 +/- 4.9 vs. 9.79 +/- 3.34 ng/ml, mean +/- SD); this did not differ by sex. The bone age fell within two standard deviations of the mean, and 9.5% of the diabetics had a bone mass deficit (less than the mean cortical thickness) greater than 2 SD. There was no correlation between osteocalcin and Ca, P, glycemia, HbA1c, PTH, Mg, or OHP. Our results do not support any association between bone mass loss and the severity or duration of type 1 diabetes. Bone turnover, measured by serum osteocalcin, was normal. Therefore the pathogenesis of osteopenia in type 1 DM remains unclear, and requires further investigation. While people with type 1 diabetes mellitus (DM) often have bone deficiency, the relation between this dificiency and the duration or control of diabetes remains controversial. To assess the possibility of such an interrelationship, we studied parameters relating to mineral metabolism (Ca, P, alkaline phosphatase, Mg, PTH, and hydroxyproline (OHP)); bone remodeling (osteocalcin); diabetic control (HbA 1c); and radiological study of the second metacarpal of the left hand and of bone age in 87 children with type 1 DM. The mineral parameters were not abnormal among the diabetics. Diabetic children had similar levels of fasting osteocalcin as normals (10.05 ± 4.9 vs. 9.79 ± 3.34 ng/ml, mean ± SD); this did not differ by sex. The bone age fell within two standard deviations of the mean, and 9.5% of the diabetics had a bone mass deficit (less than the mean cortical thickness) greater than 2 SD. There was no correlation between osteocalcin and Ca, P, glycemia, HbA 1c, PTH, Mg, or OHP. Our results do not support any association between bone mass loss and the severity or duration of type 1 diabetes. Bone turnover, measured by serum osteocalcin, was normal. Therefore the pathogenesis of osteopenia in type 1 DM remains unclear, and requires further investigation. |
Author | Leon, Miguel Larrodera, Luisa Hawkins, Federico Lledo, Gregorio |
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Cites_doi | 10.1016/B978-0-12-363705-5.50008-7 10.1210/jcem-49-3-462 10.1210/jcem-45-4-845 10.1016/0026-0495(82)90086-5 10.1007/BF00441848 10.1210/jcem-53-6-1154 10.1007/BF00422250 10.1210/jcem-59-2-228 10.1056/NEJM197601292940502 10.2337/diabetes.26.11.1052 |
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(Barcelona) contributor: fullname: Leon – year: 1976 ident: 10.1016/0168-8227(89)90035-1_BIB11 contributor: fullname: National Center for Health Statistics – start-page: 150 year: 1948 ident: 10.1016/0168-8227(89)90035-1_BIB1 contributor: fullname: Albright – volume: 5 start-page: 93 year: 1970 ident: 10.1016/0168-8227(89)90035-1_BIB8 article-title: Urinary excretion of hydroxyprolin in health and disease publication-title: Int. Rev. Connect. Tissue Res. doi: 10.1016/B978-0-12-363705-5.50008-7 contributor: fullname: Kivirikko – start-page: 12 year: 1970 ident: 10.1016/0168-8227(89)90035-1_BIB10_1 contributor: fullname: Garn – start-page: 45 year: 1970 ident: 10.1016/0168-8227(89)90035-1_BIB10_2 contributor: fullname: Garn – volume: 49 start-page: 462 year: 1979 ident: 10.1016/0168-8227(89)90035-1_BIB17 article-title: Calcium homeostasis in diabetes mellitus publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jcem-49-3-462 contributor: fullname: Heath – volume: 45 start-page: 845 year: 1977 ident: 10.1016/0168-8227(89)90035-1_BIB3 article-title: Decreased cortical thickness and osteopenia in children with diabetes mellitus publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jcem-45-4-845 contributor: fullname: Santiago – volume: 73 start-page: 3374 year: 1976 ident: 10.1016/0168-8227(89)90035-1_BIB5 article-title: Primary structure of the gamma-carboxyglutamic-acid-containing protein from bone contributor: fullname: Price – volume: 8 start-page: 918 year: 1972 ident: 10.1016/0168-8227(89)90035-1_BIB12 article-title: Prevalence of diabetes mellitus in Jerusalem: its association with presenile osteoporosis publication-title: Isr. J. Med. Sci. contributor: fullname: Menczel – volume: 31 start-page: 848 year: 1982 ident: 10.1016/0168-8227(89)90035-1_BIB15 article-title: Evaluation of bone mass and growth in young diabetics publication-title: Metabolism doi: 10.1016/0026-0495(82)90086-5 contributor: fullname: Wiske – volume: 145 start-page: 27 year: 1986 ident: 10.1016/0168-8227(89)90035-1_BIB16 article-title: Evaluation of serum osteocalcin as an index of altered bone metabolism publication-title: Eur. J. Pediatr. doi: 10.1007/BF00441848 contributor: fullname: Kruse – volume: 53 start-page: 1154 year: 1981 ident: 10.1016/0168-8227(89)90035-1_BIB14 article-title: Alterations in circulating vitamin D metabolites in the young insulin-dependent diabetic publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jcem-53-6-1154 contributor: fullname: Frazer – volume: 15 start-page: 87 year: 1978 ident: 10.1016/0168-8227(89)90035-1_BIB4 article-title: Osteopenia in insulintreated diabetes mellitus: its relation to age at onset, sex, and duration of disease publication-title: Diabetologia doi: 10.1007/BF00422250 contributor: fullname: McNair – volume: 59 start-page: 228 year: 1984 ident: 10.1016/0168-8227(89)90035-1_BIB6 article-title: Clinical evaluation of bone turnover by serum osteocalcin measurements in a hospital setting publication-title: J. Clin. Endocrinol. Metab. doi: 10.1210/jcem-59-2-228 contributor: fullname: Slovik – volume: 294 start-page: 241 year: 1976 ident: 10.1016/0168-8227(89)90035-1_BIB2 article-title: Effects of diabetes mellitus on bone mass in juvenile and adult-onset diabetes publication-title: N. Engl. J. Med. doi: 10.1056/NEJM197601292940502 contributor: fullname: Levin – volume: 26 start-page: 1052 year: 1977 ident: 10.1016/0168-8227(89)90035-1_BIB13 article-title: Diminution of bone mass in childhood publication-title: Diabetes doi: 10.2337/diabetes.26.11.1052 contributor: fullname: Rosenbloom |
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SubjectTerms | Alkaline Phosphatase - blood Blood Glucose - metabolism Blood Proteins - analysis Bone and Bones - diagnostic imaging Bone Diseases, Metabolic - etiology Bone Resorption Calcium - metabolism Calcium-Binding Proteins - blood Child Creatinine - metabolism Diabetes mellitus type 1 Diabetes Mellitus, Type 1 - physiopathology Female Glycated Hemoglobin A - analysis Humans Hydroxyproline - urine Magnesium - blood Male Osteocalcin Osteopenia Parathyroid Hormone - blood Phosphorus - metabolism Radiography Reference Values Sex Factors |
Title | Study of bone loss in diabetes mellitus type 1 |
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