Gene expression of markers associated with proliferation and differentiation in human keratinocytes cultured from epidermis and from buccal mucosa
Normal keratinocytes from epidermis and from buccal mucosa underwent dissimilar stages of differentiation in the same culture medium and responded differently to changes in the composition of the medium. Manifestations of these variations were examined in terms of the expression at the mRNA level (a...
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Published in | Archives of oral biology Vol. 40; no. 9; pp. 855 - 862 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Elsevier Ltd
01.09.1995
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Subjects | |
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Abstract | Normal keratinocytes from epidermis and from buccal mucosa underwent dissimilar stages of differentiation in the same culture medium and responded differently to changes in the composition of the medium. Manifestations of these variations were examined in terms of the expression at the mRNA level (as measured by reverse transcriptase-polymerase chain reaction) of three regulatory genes (cdc2, c-
myc, and p53) and five genes that encode structural proteins (keratins K5, K10 and K13, involucrin, and filaggrin), in three growth-medium formulations. The culture conditions enhanced or retarded maturation; the observed alterations in gene expression correlated with these changes. Except for the proliferation genes, the non-keratinizing buccal mucosa generally responded more weakly than the orthokeratotic epidermis to culture-medium supplementation favouring differentiation. Gene expression in cultured keratinocytes reflected their ability to differentiate
in vivo; genes were expressed even when the corresponding protein was not seen
in vitro. Although keratin K10 is not prevalent in the buccal mucosa nor keratin K13 in the epidermis, the genes for both were found to be expressed in both tissues. |
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AbstractList | Normal keratinocytes from epidermis and from buccal mucosa underwent dissimilar stages of differentiation in the same culture medium and responded differently to changes in the composition of the medium. Manifestations of these variations were examined in terms of the expression at the mRNA level (as measured by reverse transcriptase-polymerase chain reaction) of three regulatory genes (cdc2, c-
myc, and p53) and five genes that encode structural proteins (keratins K5, K10 and K13, involucrin, and filaggrin), in three growth-medium formulations. The culture conditions enhanced or retarded maturation; the observed alterations in gene expression correlated with these changes. Except for the proliferation genes, the non-keratinizing buccal mucosa generally responded more weakly than the orthokeratotic epidermis to culture-medium supplementation favouring differentiation. Gene expression in cultured keratinocytes reflected their ability to differentiate
in vivo; genes were expressed even when the corresponding protein was not seen
in vitro. Although keratin K10 is not prevalent in the buccal mucosa nor keratin K13 in the epidermis, the genes for both were found to be expressed in both tissues. Normal keratinocytes from epidermis and from buccal mucosa underwent dissimilar stages of differentiation in the same culture medium and responded differently to changes in the composition of the medium. Manifestations of these variations were examined in terms of the expression at the mRNA level (as measured by reverse transcriptase-polymerase chain reaction) of three regulatory genes (cdc2, c-myc, and p53) and five that encode structural proteins (keratins K5, K10 and K13, involucrin, and filaggrin), in three growth-medium formulations. The culture conditions enhanced or retarded maturation; the observed alterations in gene expression correlated with these changes. Except for the proliferation genes, the non-keratinizing buccal mucosa generally responded more weakly than the orthokeratotic epidermis to culture-medium supplementation favouring differentiation. Gene expression in cultured keratinocytes reflected their ability to differentiate in vivo; genes were expressed even when the corresponding protein was not seen in vitro. Although keratin K10 is not prevalent in the buccal mucosa nor keratin K13 in the epidermis, the genes for both were found to be expressed in both tissues. |
Author | Brysk, Henry Chen, San-Hwan Calhoun, Karen H. Tyring, Stephen K. Brysk, Miriam M. Arany, Istvan |
Author_xml | – sequence: 1 givenname: Miriam M. surname: Brysk fullname: Brysk, Miriam M. – sequence: 2 givenname: Istvan surname: Arany fullname: Arany, Istvan – sequence: 3 givenname: Henry surname: Brysk fullname: Brysk, Henry – sequence: 4 givenname: San-Hwan surname: Chen fullname: Chen, San-Hwan – sequence: 5 givenname: Karen H. surname: Calhoun fullname: Calhoun, Karen H. – sequence: 6 givenname: Stephen K. surname: Tyring fullname: Tyring, Stephen K. |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/8651890$$D View this record in MEDLINE/PubMed |
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Keywords | buccal mucosa differentiation RT-PCR, reverse transcriptase-polymerase chain reaction keratinocytes keratins involucrin p53 c- myc G3PDH, glyceraldehyde-3-phosphate dehydrogenase filaggrin gene expression cdc2 epidermis |
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SubjectTerms | buccal mucosa c- myc Calcium cdc2 Cell Differentiation - genetics Cell Division - genetics Cells, Cultured Culture Media Culture Media, Serum-Free Dentistry differentiation Epidermal Cells epidermis Epidermis - metabolism filaggrin gene expression Gene Expression Regulation Gene Expression Regulation, Enzymologic Genes, cdc - genetics Genes, myc - genetics Genes, p53 - genetics Glyceraldehyde-3-Phosphate Dehydrogenases - genetics Humans Intermediate Filament Proteins - genetics involucrin keratinocytes Keratinocytes - cytology Keratinocytes - metabolism keratins Keratins - genetics Mouth Mucosa - cytology Mouth Mucosa - metabolism p53 Polymerase Chain Reaction Protein Precursors - genetics RNA, Messenger - genetics Transcription, Genetic |
Title | Gene expression of markers associated with proliferation and differentiation in human keratinocytes cultured from epidermis and from buccal mucosa |
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