Cyclic modulation of enzymes of pyrimidine nucleotide biosynthesis precedes sialoglycoconjugate changes during 2-acetylaminofluorene-induced hepatocarcinogenesis in the rat

• Published in: Biochimica et biophysica acta Vol. 800; no. 2; pp. 194 - 201
• Main Authors: Elliott, William L., Sawick, David P., DeFrees, Shawn A., Heinstein, Peter F., Cassady, John M., James Morré, D.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 30.07.1984
• Subjects: 2-Acetylaminofluorene; Acetaminophen - toxicity; Acetylaminofluorene; Animals; Carbon-Nitrogen Ligases; Carcinogenesis (Rat liver); Dihydroorotate Oxidase - metabolism; Ligases - metabolism; Liver Neoplasms, Experimental - chemically induced; Liver Neoplasms, Experimental - enzymology; Liver Regeneration; Male; Nucleoside-Diphosphate Kinase - metabolism; Pyrimidine nucleotide synthesis; Pyrimidine Nucleotides - biosynthesis; Rats; Rats, Inbred F344; Sialoglycoconjugate change; Starvation - metabolism; Sialoglycoconjugate change; Pyrimidine nucleotide synthesis; Carcinogenesis (Rat liver); Acetylaminofluorene

Three enzymatic activities associated with pyrimidine nucleotide biosynthesis were monitored at weekly or bi-weekly intervals during 2-acetylaminofluorene- (0.025% in a Farber Basal Carcinogenic diet) induced hepatocarcinogenesis in the rat. Dihydroorotate dehydrogenase, the fourth of six enzymes in...