Attenuation of the levels of pro-inflammatory cytokines prevents depressive-like behavior during ethanol withdrawal in mice

• Published in: Brain research bulletin Vol. 191; pp. 9 - 19
• Main Authors: Fraga-Junior, E.B., Fernandes, I.L., Rohden, C.A.H., Doneda, D.L., Ynoue, H.N., Rios-Santos, F., Lima, E., Buss, Z.S., Vandresen-Filho, S.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 01.12.2022
• Subjects: Alcohol abuse disorder; Cyclooxygenase; Depression; Neuroinflammation; Vilazodone, nimesulide; Alcohol abuse disorder; Depression; Neuroinflammation; Cyclooxygenase; Vilazodone, nimesulide

Clinical studies indicate that alcohol-dependent patients may develop depressive symptoms during abstinence, which may increase the likelihood of relapse. It is known that both in alcohol exposure and depression, there is an increase in the levels of pro-inflammatory cytokines in the brain. However,...