Modulation of steroidogenic activities in testis leydig cells

• Published in: Molecular and Cellular Endocrinology Vol. 21; no. 1; pp. 15 - 28
• Main Authors: Rommerts, F.F.G., Brinkman, A.O.
• Format: Book Review Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 1981
• Subjects: Aging; Animals; Aromatase - metabolism; Cell Membrane - metabolism; Cell Separation; Cholesterol Side-Chain Cleavage Enzyme - metabolism; Chorionic Gonadotropin - administration & dosage; Chorionic Gonadotropin - pharmacology; Cycloheximide - pharmacology; Estradiol - metabolism; Follicle Stimulating Hormone - pharmacology; Gonadal Steroid Hormones - metabolism; Gonadotropin-Releasing Hormone - pharmacology; Hydroxyprogesterones - metabolism; Leydig cell; Leydig Cells - drug effects; Leydig Cells - metabolism; LH mechanism of action; Luteinizing Hormone - pharmacology; Male; oestradiol; Oxidoreductases - metabolism; Phosphorylation; Pregnenolone - metabolism; Protein Kinases - metabolism; Rats; Receptors, Cell Surface - drug effects; Receptors, LH; Sertoli Cells - drug effects; Sertoli Cells - enzymology; steroidogenesis; testosterone; Testosterone - metabolism; LH mechanism of action; steroidogenesis; oestradiol; testosterone; Leydig cell

Recent developments in the regulation of testicular Leydig-cell function support the following conclusions. 1. (1) Enzymic activities involved in steroid production in the testis are mainly localized in Leydig cells. The aromatase enzyme complex for oestrogen production appears to be localized in Le...