Effect of intranasal insulin on perioperative cognitive function in older adults: a randomized, placebo-controlled, double-blind clinical trial - Sun, Miao; Ruan, Xianghan; Zhou, Zhikang; Huo, Yuting; Liu, Min; Liu, Siyuan; Cao, Jiangbei; Liu, Yan-hong; Zhang, Xiaoying; Ma, Yu-long; Mi, Weidong (Age and ageing, 2024)
Keywords: Administration, Intranasal; Aged; Aged, 80 and over; Alternative medicine; Anesthesia; Biomarkers - blood; C-reactive protein; Clinical research; Clinical trials; Cognition - drug effects; Cognitive ability; Cognitive functioning; Cognitive impairment; Complications; Delirium; Double-Blind Method; Elective surgery; Female; Health care; Humans; Hypoglycemic Agents - administration & dosage; Hypoglycemic Agents - adverse effects; Induction; Insulin; Insulin - administration & dosage; Interleukin 6; Intranasal administration; Male; Mental Status and Dementia Tests; Mini-Mental State Examination; Nasal sprays; Necrosis; Older people; Orthopedic Procedures - adverse effects; Orthopedic surgery; Patients; Postoperative; Postoperative Cognitive Complications - diagnosis; Postoperative Cognitive Complications - epidemiology; Postoperative Cognitive Complications - etiology; Postoperative Cognitive Complications - prevention & control; Serum; Serum levels; Surgery; Time Factors; Treatment Outcome; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Tumors; older people; insulin resistance; intranasal insulin; older surgical patient; postoperative cognitive function; postoperative delirium (POD)