Lymph node cells from BALB/c mice with chronic visceral leishmaniasis exhibiting cellular anergy and apoptosis: involvement of Ser/Thr phosphatase

• Published in: Apoptosis (London) Vol. 11; no. 11; pp. 2013 - 2029
• Main Authors: Mukherjee, Piyali, Sen, Parimal C, Ghose, Asoke C
• Format: Journal Article
• Language: English
• Published: Netherlands Springer Nature B.V 01.11.2006
• Subjects: Animals; Apoptosis; bcl-2-Associated X Protein - metabolism; Cell cycle; Cell Proliferation - drug effects; Chronic Disease; Clonal Anergy; Cricetinae; Disease Models, Animal; Enzyme Inhibitors - pharmacology; Extracellular Signal-Regulated MAP Kinases - metabolism; Inactivation; Ionomycin - pharmacology; Ionophores - pharmacology; Kinases; Leishmania donovani; Leishmania donovani - immunology; Leishmaniasis, Visceral - immunology; Lymph Nodes - cytology; Lymph Nodes - immunology; Lymphocyte Activation; Lymphocytes; Lymphocytes - cytology; Lymphocytes - immunology; Mice; Mice, Inbred BALB C; Okadaic Acid - pharmacology; Parasites; Parasitic diseases; Phosphoprotein Phosphatases - metabolism; Protein Kinase C - metabolism; Proteins; Proto-Oncogene Proteins - metabolism; Proto-Oncogene Proteins c-bcl-2; Tetradecanoylphorbol Acetate - pharmacology; Vector-borne diseases

Visceral leishmaniasis (VL) produced in BALB/c mice through intracardial administration of Leishmania donovani amastigotes was accompanied by hepatosplenomegaly with high organ parasite load and lymphadenopathy when followed up to 4-months or so. To elucidate the mechanism of immunosuppression assoc...