Amine boranes as alternative reducing agents for reductive alkylation of proteins

• Published in: Analytical biochemistry Vol. 124; no. 2; pp. 272 - 278
• Main Authors: Cabacungan, Judy C., Ahmed, Ahmed I., Feeney, Robert E.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.1982
• Subjects: Alkylation; Amines; Boranes; Indicators and Reagents; Methylation; Oxidation-Reduction; Proteins - analysis; Structure-Activity Relationship

The use of several commercially available amine-borane complexes was investigated for the reductive methylation of amino groups of several proteins. An earlier study in our laboratory, using turkey ovomucoid as the model protein, showed that dimethylamine borane is a slightly weaker reducing agent,...